Technology Process of 1,3,2-Dioxaborinane, 2-(3-fluoro-4-propylphenyl)-5,5-dimethyl-
There total 6 articles about 1,3,2-Dioxaborinane, 2-(3-fluoro-4-propylphenyl)-5,5-dimethyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium; magnesium sulfate;
In
diethyl ether;
n-BuLi added to soln. of BrFC6H3C3H7 in Et2O at -78°C; after 15 min B(OiPr)3 added dropwise; warmed to room temp. overnight; H2O, Et2O, concd. HCl added; org. phase washed (H2O, brine); solvent removed (vac.);residue dissolved in Et2O;; neopentyl glycol and MgSO4 added; stirred for 1 h; solvent removed (vac.); hexane added to the oily residue; filtered; crystn. from filtrate at -25°C; elem. anal.;
DOI:10.1039/b212107g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 69.9 g / H2 / PtO2 / methanol / 12 h / 760 Torr
2.1: n-BuLi / diethyl ether / 0.25 h / -78 °C
2.2: tetrahydrofuran / -78 - 20 °C
3.1: aq. HCl / diethyl ether
4.1: 74.2 g / MgSO4 / tetrahydrofuran / 1 h
With
hydrogenchloride; n-butyllithium; hydrogen; magnesium sulfate;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; diethyl ether;
DOI:10.1039/b212107g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi / diethyl ether / 1.5 h / -78 °C
1.2: CuCN / diethyl ether / -70 - 20 °C
2.1: 69.9 g / H2 / PtO2 / methanol / 12 h / 760 Torr
3.1: n-BuLi / diethyl ether / 0.25 h / -78 °C
3.2: tetrahydrofuran / -78 - 20 °C
4.1: aq. HCl / diethyl ether
5.1: 74.2 g / MgSO4 / tetrahydrofuran / 1 h
With
hydrogenchloride; n-butyllithium; hydrogen; magnesium sulfate;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; diethyl ether;
DOI:10.1039/b212107g
