1,3,2-Dioxaborinane, 2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl-

Base Information

Chemical Name:1,3,2-Dioxaborinane, 2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl-
CAS No.:574755-21-8
Molecular Formula:C14H19BF2O2
Molecular Weight:268.111
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,3,2-Dioxaborinane, 2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl-

Chemical Property:

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Technology Process of 1,3,2-Dioxaborinane, 2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl-

There total 5 articles about 1,3,2-Dioxaborinane, 2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 5419-55-6
Triisopropyl borate

: 126-30-7
2,2-Dimethyl-1,3-propanediol

: 574755-20-7
5-bromo-1,3-difluoro-2-propylbenzene

: 574755-21-8
2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl[1,3,2]dioxaborinane

Guidance literature:: With n-butyllithium; magnesium sulfate; In diethyl ether; n-BuLi added to soln. of BrF2C6H2C3H7 in Et2O at -78°C; after 15 min B(OiPr)3 added dropwise; warmed to room temp. overnight; H2O, Et2O, concd. HCl added; org. phase washed with H2O and brine; solvent removed (vac.); residue dissolved in Et2O;; neopentyl glycol and MgSO4 added; stirred for 1 h; solvent removed (vac.); hexane added to the oily residue; filtered; crystn. from filtrate at -25°C; elem. anal.;
DOI:10.1039/b212107g

Reference yield:

: 461-96-1
3,5-difluorobromobenzene

: 574755-21-8
2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl[1,3,2]dioxaborinane

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / 1.5 h / -78 °C

1.2: 89 percent / tetrahydrofuran / -78 - 20 °C

2.1: P₂O₅ / pentane

3.1: 70.5 g / H₂ / PtO₂ / pentane / 12 h / 760 Torr

4.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

4.2: tetrahydrofuran / -78 - 20 °C

5.1: aq. HCl / diethyl ether

6.1: 36.7 g / MgSO₄ / tetrahydrofuran

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; magnesium sulfate; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1039/b212107g

Reference yield:

: 574755-19-4
1-(4-bromo-2,6-difluorophenyl)-propan-1-ol

: 574755-21-8
2-(3,5-difluoro-4-propylphenyl)-5,5-dimethyl[1,3,2]dioxaborinane

Guidance literature:: Multi-step reaction with 5 steps

1.1: P₂O₅ / pentane

2.1: 70.5 g / H₂ / PtO₂ / pentane / 12 h / 760 Torr

3.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

3.2: tetrahydrofuran / -78 - 20 °C

4.1: aq. HCl / diethyl ether

5.1: 36.7 g / MgSO₄ / tetrahydrofuran

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; magnesium sulfate; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1039/b212107g