Technology Process of Benzenemethanol, a-ethyl-2,3-difluoro-
There total 1 articles about Benzenemethanol, a-ethyl-2,3-difluoro- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ortho-difluorobenzene;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 1.5h;
propionaldehyde;
In
tetrahydrofuran;
at -78 - 20 ℃;
Further stages.;
DOI:10.1039/b212107g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: P2O5 / pentane
2: 46.3 g / H2 / PtO2 / pentane / 12 h / 760 Torr
With
hydrogen; phosphorus pentoxide;
platinum(IV) oxide;
In
pentane;
DOI:10.1039/b212107g
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: P2O5 / pentane
2.1: 46.3 g / H2 / PtO2 / pentane / 12 h / 760 Torr
3.1: n-BuLi / tetrahydrofuran / 0.25 h / -78 °C
3.2: tetrahydrofuran / -78 - 20 °C
4.1: aq. HCl / diethyl ether
5.1: 56.3 g / NgSO4 / tetrahydrofuran / 1 h
6.1: 99 percent / aq. K2CO3 / Pd(OAc)2 / acetone / 12 h / 80 °C
7.1: ICl / acetonitrile / 1 h / 20 °C
8.1: 89 percent / aq. K2CO3 / Pd(OAc)2 / acetone / 12 h / 80 °C
With
hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; Iodine monochloride; potassium carbonate;
platinum(IV) oxide; palladium diacetate;
In
tetrahydrofuran; diethyl ether; acetone; acetonitrile; pentane;
6.1: Suzuki coupling / 8.1: Suzuki coupling;
DOI:10.1039/b212107g