Technology Process of 1,3,2-Dioxaborinane, 2-(2-fluoro-4-propylphenyl)-5,5-dimethyl-
There total 7 articles about 1,3,2-Dioxaborinane, 2-(2-fluoro-4-propylphenyl)-5,5-dimethyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydrogencarbonate;
In
dichloromethane;
BBr3 added to soln. of 2-fluoro-4-propyl-1-trimethylbenzene in dry CH2Cl2 at room temp.; after 30 min soln. of neopentyl glycol in CH2Cl2 added;after 30 min satd. KHCO3 added until neutralization; org. phase washed with water and brine; dried over MgSO4; filtered; solvent removed under vac.; oily residue dissolved in hexane; filtered; crystn. from filtrate at -25°C; elem. anal.;
DOI:10.1039/b212107g
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi / diethyl ether / 1 h / -78 °C
1.2: 96 percent / DMAP / diethyl ether / -78 - 20 °C
2.1: LDA / tetrahydrofuran / 1.5 h / -78 °C
2.2: 79 percent / tetrahydrofuran / -78 - 20 °C
3.1: P2O5 / pentane
4.1: 90.1 percent / H2 / PtO2 / pentane / 12 h / 760 Torr
5.1: BBr3 / CH2Cl2 / 0.5 h / 20 °C
6.1: 26.1 g / CH2Cl2 / 0.5 h
With
n-butyllithium; hydrogen; phosphorus pentoxide; boron tribromide; lithium diisopropyl amide;
platinum(IV) oxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; pentane;
DOI:10.1039/b212107g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: LDA / tetrahydrofuran / 1.5 h / -78 °C
1.2: 79 percent / tetrahydrofuran / -78 - 20 °C
2.1: P2O5 / pentane
3.1: 90.1 percent / H2 / PtO2 / pentane / 12 h / 760 Torr
4.1: BBr3 / CH2Cl2 / 0.5 h / 20 °C
5.1: 26.1 g / CH2Cl2 / 0.5 h
With
hydrogen; phosphorus pentoxide; boron tribromide; lithium diisopropyl amide;
platinum(IV) oxide;
In
tetrahydrofuran; dichloromethane; pentane;
DOI:10.1039/b212107g
