6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one

Base Information

Chemical Name:6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one
CAS No.:57489-62-0
Molecular Formula:C₁₆H₁₅NO₂
Molecular Weight:253.301
Hs Code.:
DSSTox Substance ID:DTXSID30607501

Synonyms:57489-62-0;6-(Dimethylamino)-3-phenylisobenzofuran-1(3H)-one;6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one;SCHEMBL11063311;DTXSID30607501

Suppliers and Price of 6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:253.110278721
Heavy Atom Count:19
Complexity:336

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=CC2=C(C=C1)C(OC2=O)C3=CC=CC=C3

Technology Process of 6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one

There total 3 articles about 6-(Dimethylamino)-3-phenyl-2-benzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-Dimethylamino-N,N-diethyl-2-(hydroxy-phenyl-methyl)-benzamide

: 57489-62-0
3-phenyl-6-dimethylaminophthalide

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 48h; Yield given; Heating;
DOI:10.1016/S0040-4020(01)81579-9

Reference yield:

: 100-52-7
benzaldehyde

: 57489-62-0
3-phenyl-6-dimethylaminophthalide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) s-BuLi, N,N,N,N-tetramethylethylene diamine / 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h

2: p-TsOH / toluene / 48 h / Heating

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; toluene-4-sulfonic acid; In toluene;
DOI:10.1016/S0040-4020(01)81579-9

Reference yield:

: 143024-52-6
3-Dimethylamino-N,N-diethyl-benzamide

: 57489-62-0
3-phenyl-6-dimethylaminophthalide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) s-BuLi, N,N,N,N-tetramethylethylene diamine / 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h

2: p-TsOH / toluene / 48 h / Heating

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; toluene-4-sulfonic acid; In toluene;
DOI:10.1016/S0040-4020(01)81579-9