6,7-Dimethyl-2-phenylquinoxaline

Base Information

Chemical Name:6,7-Dimethyl-2-phenylquinoxaline
CAS No.:71897-07-9
Molecular Formula:C16H14N2
Molecular Weight:234.301
Hs Code.:2933990090
NSC Number:380341
UNII:FWH2FYS649
DSSTox Substance ID:DTXSID10274351
Nikkaji Number:J600.111D
Wikidata:Q27074334
NCI Thesaurus Code:C2031
ChEMBL ID:CHEMBL7724
Mol file:71897-07-9.mol

Synonyms:6,7-dimethoxy-2-phenylquinoxaline;AG 1295;AG-1295;AG1295

Suppliers and Price of 6,7-Dimethyl-2-phenylquinoxaline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AG 1295
100mg
$ 995.00

Sigma-Aldrich
AG 1295
5mg
$ 124.00

ChemScene
AG 1295 99.88%
50mg
$ 400.00

ChemScene
AG 1295 99.88%
5mg
$ 78.00

ChemScene
AG 1295 99.88%
10mg
$ 133.00

Cayman Chemical
AG 1295 ≥98%
5mg
$ 81.00

Cayman Chemical
AG 1295 ≥98%
10mg
$ 150.00

Cayman Chemical
AG 1295 ≥98%
1mg
$ 25.00

Cayman Chemical
AG 1295 ≥98%
25mg
$ 313.00

ApexBio Technology
AG 1295
25mg
$ 435.00

Total 12 raw suppliers

Chemical Property of 6,7-Dimethyl-2-phenylquinoxaline

Chemical Property:

Vapor Pressure:3.42E-06mmHg at 25°C
Melting Point:121 °C
Boiling Point:398.3°Cat760mmHg
PKA:1.29±0.30(Predicted)
Flash Point:172.4°C
PSA：25.78000
Density:1.127g/cm³
LogP:3.91360
Storage Temp.:−20°C
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:234.115698455
Heavy Atom Count:18
Complexity:272

Purity/Quality:

99%, ^*data from raw suppliers

AG 1295 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=NC=C(N=C2C=C1C)C3=CC=CC=C3
Description Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1295 is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGF receptor kinase in vitro and in Swiss 3T3 cells (IC50s range from 0.3-1 μM). It inhibits PDGF-stimulated DNA synthesis with an IC50 value of 2.5 μM without affecting activity of the EGF receptor.
Uses AG-1295 is a protein tyrosine kinase inhibitor. Antiproliferative agent used in the treatment of atherosclerosis, pulmonary fibrosis, and gliomas.

Technology Process of 6,7-Dimethyl-2-phenylquinoxaline

There total 42 articles about 6,7-Dimethyl-2-phenylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 3171-45-7
4,5-dimethyl-1,2-phenylenediamine

: 70-11-1
α-bromoacetophenone

: 71897-07-9
AG₁₂₉₅

Guidance literature:: With 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate; at 70 ℃; for 0.983333h; Green chemistry;
DOI:10.4067/S0717-97072016000100018

Reference yield: 97.9%

: 6972-71-0
4,5-dimethyl-2-nitrobenzenamine

: 102921-26-6,93-52-7
(1,2-dibromoethyl)benzene

: 71897-07-9
AG₁₂₉₅

Guidance literature:: With N-hexylpyridine hexafluorophosphate; cisplatine; 4,7-Dimethyl-1,10-phenanthroline; diisopropanolamine; In toluene; at 120 ℃; for 8h; Reagent/catalyst; Inert atmosphere;

Reference yield: 96.0%

: 582-24-1
1-phenyl-2-hydroxyethanone

: 3171-45-7
4,5-dimethyl-1,2-phenylenediamine

: 71897-07-9
AG₁₂₉₅

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(II) acetate monohydrate; In N,N-dimethyl-formamide; at 110 ℃; for 0.5h; Microwave irradiation;
DOI:10.1080/00397911.2015.1022660