7-Bromo-2-methylbenzofuran

Base Information

• Chemical Name: 7-Bromo-2-methylbenzofuran
• CAS No.: 57547-15-6
• Molecular Formula: C9H7BrO
• Molecular Weight: 211.058
• European Community (EC) Number: 829-514-0
• ChEMBL ID: CHEMBL3273876

Synonyms:7-bromo-2-methylbenzofuran;57547-15-6;7-bromo-2-methyl-1-benzofuran;MFCD18451224;Benzofuran, 7-bromo-2-methyl-;2-methyl-7-bromobenzofuran;7-bromo-2-methyl-benzofuran;SCHEMBL1800952;CHEMBL3273876;RLVGRFODLCTVTN-UHFFFAOYSA-N;AKOS022691247;AS-40481;SY045664;CS-0453790;EN300-108054;A914915;Z1269204422

Chemical Property of 7-Bromo-2-methylbenzofuran

Chemical Property:

• PSA: 13.14000
• LogP: 3.50370
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 209.96803
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-2-methylbenzofuran 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC2=C(O1)C(=CC=C2)Br

Technology Process of 7-Bromo-2-methylbenzofuran

There total 10 articles about 7-Bromo-2-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

7-bromobenzo(b)furan (133720-60-2) + methyl iodide (74-88-4) → 7-bromo-2-methylbenzofuran (57547-15-6)

Guidance literature:

7-bromobenzo(b)furan; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield: 73.0%

1-bromo-2-(prop-2-yn-1-yloxy)benzene (38770-76-2) → 7-bromo-2-methylbenzofuran (57547-15-6)

Guidance literature:

With cesium fluoride; N,N-diethylaniline; for 4h; Heating;

DOI:10.1248/cpb.41.1166

Reference yield: 69.0%

2-bromo-6-(2-bromoallyl)phenol (188714-81-0) → 7-bromo-2-methylbenzofuran (57547-15-6)

Guidance literature:

With sodium ethanolate; In ethanol; for 5h; Heating;

DOI:10.1016/S0968-0896(96)00244-1

upstream raw materials:

1-bromo-2-(prop-2-yn-1-yloxy)benzene

2-bromo-6-(2-bromoallyl)phenol

methyl iodide

2-hydroxybromobenzene

Downstream raw materials:

2-hydroxy-3-bromobenzaldehyde

7-bromo-2-hydroxy-2-methyl-2,3-dihydrobenzofuran-3(2H)-one

5-[2-(2-Methyl-benzofuran-7-yl)-phenyl]-1-trityl-1H-tetrazole

1-benzyl-3-methyl-4-hydroxy-4-(2-methylbenzofuran-7-yl)piperidine

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