4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Base Information

Chemical Name:4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS No.:57724-78-4
Molecular Formula:C18H19NO3
Molecular Weight:297.354
Hs Code.:
ChEMBL ID:CHEMBL289253
DSSTox Substance ID:DTXSID80561427

Synonyms:CHEMBL289253;57724-78-4;4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one;SCHEMBL3547095;DTXSID80561427;QLIBRFKGUKUNLP-UHFFFAOYSA-N;BDBM50017096;4-(3-Benzyloxy-4-methoxyphenyl)-2-pyrrolidone;4-(3-benzyloxy-4-methoxyphenyl)-pyrrolidin-2-one;4-(3-Benzyloxy-4-methoxy-phenyl)-pyrrolidin-2-one

Suppliers and Price of 4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:297.13649347
Heavy Atom Count:22
Complexity:367

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2CC(=O)NC2)OCC3=CC=CC=C3

Technology Process of 4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one

There total 7 articles about 4-[3-(Benzyloxy)-4-methoxyphenyl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 121191-46-6
Methyl 3-<3-(benzyloxy)-4-methoxyphenyl>-4-nitrobutyrate

: 57724-78-4
4-(3-benzyloxy-4-methoxyphenyl)-2-pyrrolidone

Guidance literature:: Methyl 3-<3-(benzyloxy)-4-methoxyphenyl>-4-nitrobutyrate; With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 ℃; for 1.5h;

With potassium carbonate; In methanol; at 0 ℃; for 18h;

Reference yield: 74.0%

: 1295626-42-4
3-(3-benzyloxy-4-methoxyphenyl)-4-nitrobutanoic acid

: 57724-78-4
4-(3-benzyloxy-4-methoxyphenyl)-2-pyrrolidone

Guidance literature:: 3-(3-benzyloxy-4-methoxyphenyl)-4-nitrobutanoic acid; With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 ℃; for 1h;

With potassium carbonate; In methanol; at 0 - 20 ℃; for 18h;

Reference yield:

: 316805-93-3
3-Benzylisoferulic acid methyl ester

: 57724-78-4
4-(3-benzyloxy-4-methoxyphenyl)-2-pyrrolidone

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / 1,1,3,3-tetramethylguanidine / 27 h / 70 °C

2: 55 percent / H₂ / Raney nickel / methanol / 10 h / 60 °C

With hydrogen; N,N,N',N'-tetramethylguanidine; nickel; In methanol;
DOI:10.1021/jm00127a009