4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone

Base Information

• Chemical Name: 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone
• CAS No.: 179864-51-8
• Molecular Formula: C₁₇H₂₃NO₅
• Molecular Weight: 321.373
• Mol file: 179864-51-8.mol

Synonyms:4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone

Chemical Property of 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone

There total 7 articles about 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(3-hydroxy-4-methoxyphenyl)-pyrrolidin-2-one (57724-60-4) + Ethyl 4-bromobutyrate (2969-81-5) → 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone (179864-51-8)

Guidance literature:

With potassium carbonate; potassium iodide; In dimethyl sulfoxide; for 12h; Ambient temperature;

DOI:10.1021/jm00127a009

Reference yield:

4-(3-benzyloxy-4-methoxyphenyl)-2-pyrrolidone (57724-78-4) → 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone (179864-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / H₂, HClO₄ / 10percent Pd/C / ethanol / 12 h

2: 75 percent / K₂CO₃, KI / dimethylsulfoxide / 12 h / Ambient temperature

With perchloric acid; hydrogen; potassium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00127a009

Reference yield:

3-Benzylisoferulic acid methyl ester (316805-93-3) → 4-(3-{[(Ethoxycarbonyl)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone (179864-51-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 1,1,3,3-tetramethylguanidine / 27 h / 70 °C

2: 55 percent / H₂ / Raney nickel / methanol / 10 h / 60 °C

3: 75 percent / H₂, HClO₄ / 10percent Pd/C / ethanol / 12 h

4: 75 percent / K₂CO₃, KI / dimethylsulfoxide / 12 h / Ambient temperature

With perchloric acid; hydrogen; potassium carbonate; potassium iodide; N,N,N',N'-tetramethylguanidine; palladium on activated charcoal; nickel; In methanol; ethanol; dimethyl sulfoxide;

DOI:10.1021/jm00127a009

upstream raw materials:

4-(3-hydroxy-4-methoxyphenyl)-pyrrolidin-2-one

Ethyl 4-bromobutyrate

4-(3-benzyloxy-4-methoxyphenyl)-2-pyrrolidone

3-Benzylisoferulic acid methyl ester

Downstream raw materials:

4-(3-{[(Carboxy)propyl]oxy}-4-methoxyphenyl)-2-pyrrolidinone