4-amino-2-phenylbutanoic acid (HCl)

Base Information

• Chemical Name: 4-amino-2-phenylbutanoic acid (HCl)
• CAS No.: 66859-48-1
• Molecular Formula: C₁₀H₁₃NO₂*ClH
• Molecular Weight: 215.68
• Hs Code.: 2922499990
• Mol file: 66859-48-1.mol

Synonyms:BUTYRIC ACID,4-AMINO-2-PHENYL-,HYDROCHLORIDE;

Chemical Property of 4-amino-2-phenylbutanoic acid (HCl)

Chemical Property:

• Boiling Point: 328.9°Cat760mmHg
• Flash Point: 152.7°C
• PSA: 63.32000
• Density: 1.161g/cm³
• LogP: 2.70590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-2-phenylbutanoicacidhydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-2-phenylbutanoic acid (HCl)

There total 9 articles about 4-amino-2-phenylbutanoic acid (HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(R)-(-)-4-benzoylamino-2-phenyl-butyric acid (918149-84-5) → (R)-(-)-4-amino-2-phenyl-butyric acid hydrochloride (66859-48-1)

Guidance literature:

With hydrogenchloride; for 18h; Heating;

DOI:10.1021/jo061664f

Reference yield: 90.0%

2-(2-Amino-ethyl)-2-phenyl-malonic acid diethyl ester; hydrochloride (67465-34-3) → 4-amino-2-phenylbutanoic acid hydrochloride (66859-48-1)

Guidance literature:

With hydrogenchloride; for 16h; Heating;

DOI:10.1071/C97031

Reference yield:

diethyl 2-phenylmalonate (83-13-6) → 4-amino-2-phenylbutanoic acid hydrochloride (66859-48-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature

2: 68 percent / H₂ / PtO₂

3: 90 percent / aq. HCl / 16 h / Heating

With hydrogenchloride; hydrogen; sodium hydride; platinum(IV) oxide; In tetrahydrofuran;

DOI:10.1071/C97031

upstream raw materials:

2-(2-Amino-ethyl)-2-phenyl-malonic acid diethyl ester; hydrochloride

diethyl (2-cyanomethyl)-2-phenylpropanedioate

diethyl 2-phenylmalonate

(R)-(-)-4-benzoylamino-2-phenyl-butyric acid