2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(1S,2S,5R)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl] bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl-

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Chemical Name:2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(1S,2S,5R)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl] bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl-
CAS No.:577991-19-6
Molecular Formula:C35H36N2O4Si
Molecular Weight:576.767
Hs Code.:

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Chemical Property of 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(1S,2S,5R)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl] bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl-

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Technology Process of 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(1S,2S,5R)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl] bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl-

There total 14 articles about 2,4(1H,3H)-Pyrimidinedione, 3-benzoyl-1-[(1S,2S,5R)-5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl] bicyclo[3.1.0]hex-3-en-2-yl]-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 4330-20-5
N-3-benzoylthymine

: 577991-18-5
(1S,2R,5R)-5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-ol

: 577991-19-6
(1'S,2'S,5'R)-1-{5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl}-5-methyl-3-(phenylcarbonyl)-1,3-dihydropyrimidine-2,4-dione

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm030116g

Reference yield:

: 259659-49-9
(1S,2R,4S,5R)-4-(phenylmethoxy)-5-[(phenylmethoxy)methyl]bicyclo[3.1.0]hexan-2-ol

: 577991-19-6
(1'S,2'S,5'R)-1-{5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl}-5-methyl-3-(phenylcarbonyl)-1,3-dihydropyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

2: 72.5 percent / formic acid / Pd black / methanol / 20 °C

3: 81 percent / imidazole / CH₂Cl₂ / 2 h / 0 °C

4: 100 percent / triphenylphosphine; imidazole; iodine / toluene / 1 h / 100 °C

5: 51 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 100 °C

6: 97 percent / NaOMe / methanol / 20 °C

7: 45 percent / diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With pyridine; 1H-imidazole; formic acid; iodine; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; palladium; In tetrahydrofuran; methanol; dichloromethane; toluene; 7: Mitsunobu coupling;
DOI:10.1021/jm030116g

Reference yield:

: 577991-15-2
(1S,2R,4S,5R)-4-[(phenylmethoxy)-5-(phenylmethoxy)methyl]bicyclo[3.1.0]hex-2-yl benzoate

: 577991-19-6
(1'S,2'S,5'R)-1-{5-[(2,2-dimethyl-1,1-diphenyl-1-silapropoxy)methyl]bicyclo[3.1.0]hex-3-en-2-yl}-5-methyl-3-(phenylcarbonyl)-1,3-dihydropyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 72.5 percent / formic acid / Pd black / methanol / 20 °C

2: 81 percent / imidazole / CH₂Cl₂ / 2 h / 0 °C

3: 100 percent / triphenylphosphine; imidazole; iodine / toluene / 1 h / 100 °C

4: 51 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 24 h / 100 °C

5: 97 percent / NaOMe / methanol / 20 °C

6: 45 percent / diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; formic acid; iodine; sodium methylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; diethylazodicarboxylate; palladium; In tetrahydrofuran; methanol; dichloromethane; toluene; 6: Mitsunobu coupling;
DOI:10.1021/jm030116g