5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid
CAS No.:57861-20-8
Molecular Formula:C11H11N3O2
Molecular Weight:217.227
Hs Code.:
European Community (EC) Number:660-506-8

Synonyms:57861-20-8;5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid;SCHEMBL10488953;3-Methyl-5-(phenylamino)-1H-pyrazole-4-carboxylic acid

Suppliers and Price of 5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:217.085126602
Heavy Atom Count:16
Complexity:254

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=NN1)NC2=CC=CC=C2)C(=O)O

Technology Process of 5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid

There total 4 articles about 5-anilino-3-methyl-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4501-60-4
4-ethoxycarbonyl-3-methyl-5-phenylamino-1H-pyrazole

: 57861-20-8
3-anilino-5-methyl-4-pyrazolcarboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 8h; Heating;
DOI:10.1135/cccc19920656

Reference yield:

: 103-72-0
phenyl isothiocyanate

: 57861-20-8
3-anilino-5-methyl-4-pyrazolcarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: aq. sodium chloroacetate, hydrazine / ethanol / 4 h / Ambient temperature

2: 68 percent / ethanol / a) RT, 8 h, b) reflux, 2 h

3: 88 percent / 5percent aq. NaOH / ethanol / 8 h / Heating

With sodium hydroxide; sodium monochloroacetic acid; hydrazine; In ethanol;
DOI:10.1135/cccc19920656

Reference yield:

: 62-53-3
aniline

: 57861-20-8
3-anilino-5-methyl-4-pyrazolcarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: aq. ammonia / ethanol / 4 h / Ambient temperature

2: aq. sodium chloroacetate, hydrazine / ethanol / 4 h / Ambient temperature

3: 68 percent / ethanol / a) RT, 8 h, b) reflux, 2 h

4: 88 percent / 5percent aq. NaOH / ethanol / 8 h / Heating

With ammonium hydroxide; sodium hydroxide; sodium monochloroacetic acid; hydrazine; In ethanol;
DOI:10.1135/cccc19920656