1-chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol

Base Information

• Chemical Name: 1-chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol
• CAS No.: 578742-26-4
• Molecular Formula: C14H18ClF3N2O
• Molecular Weight: 322.75400
• Mol file: 578742-26-4.mol

Synonyms:1-Chloro-3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-propan-2-ol;

Chemical Property of 1-chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol

Chemical Property:

• Melting Point: 67 - 69 °C (hexane)
• PSA: 26.71000
• LogP: 2.43000

Purity/Quality:

95%-98% ^*data from raw suppliers

1-Chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol ^*data from reagent suppliers

Safty Information:

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Technology Process of 1-chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol

There total 1 articles about 1-chloro-3-{4-[3-(trifluoromethyl)phenyl]piperazino}-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3-Trifluoromethylphenyl)piperazine (15532-75-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-hydroxy-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propyl chloride (578742-26-4)

Guidance literature:

In ethanol; at 20 ℃;

DOI:10.1016/S0014-827X(02)01302-2

Reference yield: 83.0%

endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide (21715-90-2,397299-61-5) + 2-hydroxy-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propyl chloride (578742-26-4) → 4-[3-[4-(3-trifluoromethylphenyl)piperazin-1-yl]propoxy-2-ol]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

Guidance literature:

With sodium hydroxide; In ethanol; at 70 ℃; for 24h;

DOI:10.1002/ardp.201400174

Reference yield: 82.0%

4-methoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (26413-70-7) + 2-hydroxy-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propyl chloride (578742-26-4) → 2-{2-hydroxy-3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-propyl}-4-methoxy-6-methyl-pyrrolo[3,4-c]pyridine-1,3-dione

Guidance literature:

4-methoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine; With potassium ethoxide; In ethanol; for 0.25h; Heating;

2-hydroxy-3-[4-(3-trifluoromethylphenyl)-1-piperazinyl]propyl chloride; With ethanol; Heating;

DOI:10.1016/S0014-827X(02)01302-2

upstream raw materials:

1-(3-Trifluoromethylphenyl)piperazine

epichlorohydrin

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