8-(4-Piperidinyl)-1,4-dioxa-8-azaspiro[4.5]decane

Base Information

• Chemical Name: 8-(4-Piperidinyl)-1,4-dioxa-8-azaspiro[4.5]decane
• CAS No.: 579500-30-4
• Molecular Formula: C12H22N2O2
• Molecular Weight: 226.319
• DSSTox Substance ID: DTXSID401235012
• Mol file: 579500-30-4.mol

Synonyms:579500-30-4;8-(4-Piperidinyl)-1,4-dioxa-8-azaspiro[4.5]decane;8-(Piperidin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane;SCHEMBL5519099;DTXSID401235012;AB7718;MFCD16249944;CS-0453859;8-piperidin-4-yl-1,4-dioxa-8-azaspiro[4.5]decane

Chemical Property of 8-(4-Piperidinyl)-1,4-dioxa-8-azaspiro[4.5]decane

Chemical Property:

• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 226.168127949
• Heavy Atom Count: 16
• Complexity: 225

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1N2CCC3(CC2)OCCO3

Technology Process of 8-(4-Piperidinyl)-1,4-dioxa-8-azaspiro[4.5]decane

There total 3 articles about 8-(4-Piperidinyl)-1,4-dioxa-8-azaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-[(benzyloxy)carbonyl]-4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-piperidine (880462-11-3) → 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-piperidine (579500-30-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 2h;

DOI:10.1002/anie.200502991

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-piperidine (579500-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: 98 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;

DOI:10.1002/anie.200502991

Reference yield:

piperidine-4,4-diol hydrochloride (40064-34-4) → 4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-piperidine (579500-30-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / Na₂CO₃ / dioxane; H₂O / 2 h / 20 °C

2: 56 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

3: 98 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane;

DOI:10.1002/anie.200502991

upstream raw materials:

N-[(benzyloxy)carbonyl]-4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-piperidine

benzyl 4-oxo-1-piperidinecarboxylate

piperidine-4,4-diol hydrochloride