1,3-Dimethyl-6-(4-methoxyanilino)uracil

Base Information

• Chemical Name: 1,3-Dimethyl-6-(4-methoxyanilino)uracil
• CAS No.: 58137-44-3
• Molecular Formula: C13H15N3O3
• Molecular Weight: 261.28
• DSSTox Substance ID: DTXSID00435398
• Nikkaji Number: J1.093.787F
• Wikidata: Q82250300
• Mol file: 58137-44-3.mol

Synonyms:1,3-Dimethyl-6-(4-methoxyanilino)uracil;58137-44-3;6-(4-methoxyanilino)-1,3-dimethylpyrimidine-2,4-dione;AI-204/31710048;Oprea1_264361;DTXSID00435398;SR-01000431383;SR-01000431383-1;6-(4-methoxyanilino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione

Chemical Property of 1,3-Dimethyl-6-(4-methoxyanilino)uracil

Chemical Property:

• PSA: 65.26000
• LogP: 0.90920
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 261.11134135
• Heavy Atom Count: 19
• Complexity: 400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=CC(=O)N(C1=O)C)NC2=CC=C(C=C2)OC

Technology Process of 1,3-Dimethyl-6-(4-methoxyanilino)uracil

There total 2 articles about 1,3-Dimethyl-6-(4-methoxyanilino)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,3-Dimethyl-6-chlorouracil (6972-27-6) + 4-methoxy-aniline (104-94-9) → 6-p-Methoxyphenylamino-1,3-dimethyluracil (58137-44-3)

Guidance literature:

In neat (no solvent); at 180 ℃; for 3h;

Reference yield:

→ 6-p-Methoxyphenylamino-1,3-dimethyluracil (58137-44-3)

Guidance literature:

1,3-Dimethyl-6-amino-uracil, 4-Methoxy-anilin*HCl;

Reference yield: 92.0%

indan-1,2,3-trione hydrate (485-47-2) + 6-p-Methoxyphenylamino-1,3-dimethyluracil (58137-44-3) → C22H17N3O6 (1257251-85-6)

Guidance literature:

indan-1,2,3-trione hydrate; 6-p-Methoxyphenylamino-1,3-dimethyluracil; With acetic acid; at 25 ℃; for 1h;

With lead(IV) tetraacetate; at 25 ℃; for 4h;

DOI:10.1016/j.tetlet.2010.08.113

upstream raw materials:

1,3-Dimethyl-6-chlorouracil

4-methoxy-aniline

Downstream raw materials:

1,3-dimethyl-7-methoxypyrimido<4,5-b>quinoline-2,4(1H,3H)-dione

3-(4-Methoxy-phenyl)-4,6-dimethyl-3,4-dihydro-[1,2,3]triazolo[4,5-d]pyrimidine-5,7-dione

NCNMe₂

C₂₂H₁₇N₃O₆