L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteinyl-L-a- aspartyl-S-(triphenylmethyl)-, bis(1,1-dimethylethyl) ester

Base Information

Chemical Name:L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteinyl-L-a- aspartyl-S-(triphenylmethyl)-, bis(1,1-dimethylethyl) ester
CAS No.:581799-99-7
Molecular Formula:C71H71N3O8S2
Molecular Weight:1158.49
Hs Code.:

L-Cysteine,
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteinyl-L-a-
aspartyl-S-(triphenylmethyl)-, bis(1,1-dimethylethyl) ester

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Chemical Property of L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteinyl-L-a- aspartyl-S-(triphenylmethyl)-, bis(1,1-dimethylethyl) ester

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Technology Process of L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteinyl-L-a- aspartyl-S-(triphenylmethyl)-, bis(1,1-dimethylethyl) ester

There total 4 articles about L-Cysteine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-S-(triphenylmethyl)-L-cysteinyl-L-a- aspartyl-S-(triphenylmethyl)-, bis(1,1-dimethylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 103213-32-7,167015-11-4
N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

: 581799-98-6
3-amino-N-(1-tert-butoxycarbonyl-2-tritylsulfanyl-ethyl)-succinamic acid tert-butyl ester

: 581799-99-7
N-(1-tert-butoxycarbonyl-2-tritylsulfanyl-ethyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-succinamic acid tert-butyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 5 ℃; for 19h;
DOI:10.1016/S0045-2068(03)00022-1

Reference yield:

: 71989-14-5
Fmoc-(tBu)Asp-OH

: 581799-99-7
N-(1-tert-butoxycarbonyl-2-tritylsulfanyl-ethyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / DCCI / tetrahydrofuran / 19 h / 0 - 5 °C

2: 95 percent / DBU / CH₂Cl₂ / 0.33 h / 20 °C

3: 94 percent / DCCI / tetrahydrofuran / 19 h / 0 - 5 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0045-2068(03)00022-1

Reference yield:

: 76587-61-6
S-(triphenylmethyl)-L-cysteine tert-butyl ester

: 581799-99-7
N-(1-tert-butoxycarbonyl-2-tritylsulfanyl-ethyl)-3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionylamino]-succinamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / DCCI / tetrahydrofuran / 19 h / 0 - 5 °C

2: 95 percent / DBU / CH₂Cl₂ / 0.33 h / 20 °C

3: 94 percent / DCCI / tetrahydrofuran / 19 h / 0 - 5 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0045-2068(03)00022-1