4H-Pyridazino(4,5-b)indol-4-one, 3,5-dihydro-, hydrazone

Base Information

• Chemical Name: 4H-Pyridazino(4,5-b)indol-4-one, 3,5-dihydro-, hydrazone
• CAS No.: 74377-94-9
• Molecular Formula: C₁₀H₉N₅
• Molecular Weight: 199.215
• NSC Number: 339348
• DSSTox Substance ID: DTXSID00225372
• Wikidata: Q83104330
• Mol file: 74377-94-9.mol

Synonyms:74377-94-9;4H-Pyridazino(4,5-b)indol-4-one, 3,5-dihydro-, hydrazone;3,5-Dihydro-4H-pyridazino(4,5-b)indol-4-one hydrazone;BRN 0527696;5H-pyridazino[4,5-b]indol-4-ylhydrazine;NSC339348;DTXSID00225372;AKOS006333448;NSC 339348;NSC-339348;4-hydrazino-5h-pyridazino [4,5-b]indole;LS-129707

Chemical Property of 4H-Pyridazino(4,5-b)indol-4-one, 3,5-dihydro-, hydrazone

Chemical Property:

• Vapor Pressure: 8.22E-16mmHg at 25°C
• Boiling Point: 630.6°Cat760mmHg
• Flash Point: 335.2°C
• Density: 1.543g/cm³
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 199.08579531
• Heavy Atom Count: 15
• Complexity: 234

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=CN=NC(=C3N2)NN

Technology Process of 4H-Pyridazino(4,5-b)indol-4-one, 3,5-dihydro-, hydrazone

There total 5 articles about 4H-Pyridazino(4,5-b)indol-4-one, 3,5-dihydro-, hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-4-hydrazino-5H-pyridazino<4,5-b>indole (80985-58-6) → 4-hydrazino-5H-pyridazino<4,5-b>indole (74377-94-9)

Guidance literature:

With sodium hydroxide; sodium tetrahydroborate; In 1,4-dioxane; for 10h; Ambient temperature;

DOI:10.1002/jhet.5570180808

Reference yield:

1,4-dioxo-1,2,3,4-tetrahydro-5H-pyridazino<4,5-b>indole (80985-55-3) → 4-hydrazino-5H-pyridazino<4,5-b>indole (74377-94-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / POCl₃ / 4 h / 90 °C

2: 85 percent / 98percent N₂H₄*H₂O / 6 h / Heating

3: NaBH₄/10percent NaOH / dioxane / 10 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; hydrazine hydrate; trichlorophosphate; In 1,4-dioxane;

DOI:10.1002/jhet.5570180808

Reference yield:

1H-indole-2,3-dicarboxylic acid dimethyl ester (54781-93-0) → 4-hydrazino-5H-pyridazino<4,5-b>indole (74377-94-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / 98percent N₂H₄*H₂O / ethanol / 10 h / Heating

2: 90 percent / POCl₃ / 4 h / 90 °C

3: 85 percent / 98percent N₂H₄*H₂O / 6 h / Heating

4: NaBH₄/10percent NaOH / dioxane / 10 h / Ambient temperature

With sodium hydroxide; sodium tetrahydroborate; hydrazine hydrate; trichlorophosphate; In 1,4-dioxane; ethanol;

DOI:10.1002/jhet.5570180808

upstream raw materials:

1-chloro-4-hydrazino-5H-pyridazino<4,5-b>indole

1,4-dioxo-1,2,3,4-tetrahydro-5H-pyridazino<4,5-b>indole

1H-indole-2,3-dicarboxylic acid dimethyl ester

1,4-dichloro-5H-pyridazino<4,5-b>indole

Downstream raw materials:

3-Phenyl-10H-1,2,3a,4,10-pentaaza-cyclopenta[a]fluorene