Benzenecarboximidic acid, N-[2,6-bis(1-methylethyl)phenyl]-, 1,2-dimethylhydrazide

Base Information

• Chemical Name: Benzenecarboximidic acid, N-[2,6-bis(1-methylethyl)phenyl]-, 1,2-dimethylhydrazide
• CAS No.: 582314-35-0
• Molecular Formula: C21H29N3
• Molecular Weight: 323.481
• Mol file: 582314-35-0.mol

Synonyms:

Chemical Property of Benzenecarboximidic acid, N-[2,6-bis(1-methylethyl)phenyl]-, 1,2-dimethylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarboximidic acid, N-[2,6-bis(1-methylethyl)phenyl]-, 1,2-dimethylhydrazide

There total 2 articles about Benzenecarboximidic acid, N-[2,6-bis(1-methylethyl)phenyl]-, 1,2-dimethylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dimethylhydrazine hydrochloride (73664-86-5) + (Z)-N-[2,6-di(2-propyl)phenyl]benzenecarboximidoyl chloride (1056124-67-4) → N-(2,6-diisopropylphenyl)-N'-methyl-N'-(methylamino)benzamidine (582314-35-0)

Guidance literature:

With triethylamine; In ethanol; dichloromethane; at 20 ℃; for 1h;

DOI:10.1002/ejic.200300405

Reference yield:

N-(2,6-diisopropylphenyl)benzamide (35336-02-8) → N-(2,6-diisopropylphenyl)-N'-methyl-N'-(methylamino)benzamidine (582314-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Heating

2: 1.10 g / triethylamine / ethanol; CH₂Cl₂ / 1 h / 20 °C

With thionyl chloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1002/ejic.200300405

Reference yield: 95.0%

titanium tetrachloride (7550-45-0) + N-(2,6-diisopropylphenyl)-N'-methyl-N'-(methylamino)benzamidine (582314-35-0) → trichloro[N-(2,6-diisopropylphenyl)-N'-methylamino-N'-methylbenzamidinato]titanium(IV) (791811-52-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; pentane; byproducts: LiCl; Ar, to a soln. of amidino compd. (THF) added a soln. of Li compd. (pentane) at -80°C, stirred for 1 h, TiCl4 (1.2 equiv.) added, stirred without cooling overnight; volatiles removed (vac.), residue dissolved (CH2Cl2), filtered, solvent removed (vac.), triturated (hexane), solvent removed, ppt. dried (vac.);elem. anal.;

DOI:10.1002/ejic.200300405

upstream raw materials:

1,2-dimethylhydrazine hydrochloride

(Z)-N-[2,6-di(2-propyl)phenyl]benzenecarboximidoyl chloride

N-(2,6-diisopropylphenyl)benzamide

Downstream raw materials:

dibromo[N-(2,6-diisopropylphenyl)-N'-methylamino-N'-methylbenzamidinato]nickel(II)

trichloro[N-(2,6-diisopropylphenyl)-N'-methylamino-N'-methylbenzamidinato]titanium(IV)

Refernces