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4-Methylphenylsulfonylurea

Base Information Edit
  • Chemical Name:4-Methylphenylsulfonylurea
  • CAS No.:1694-06-0
  • Molecular Formula:C8H10N2O3S
  • Molecular Weight:214.245
  • Hs Code.:2935009090
  • European Community (EC) Number:216-900-3
  • UNII:Q9W3K7K5XB
  • DSSTox Substance ID:DTXSID90168704
  • Nikkaji Number:J60.111J
  • Wikidata:Q72495368
  • Mol file:1694-06-0.mol
4-Methylphenylsulfonylurea

Synonyms:4-tolylsulfonylurea;p-tolylsulfonylurea

Suppliers and Price of 4-Methylphenylsulfonylurea
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • N-(p-Toluenesulfonyl)urea
  • 50g
  • $ 460.00
  • TCI Chemical
  • p-Toluenesulfonylurea >98.0%(HPLC)(T)
  • 5g
  • $ 135.00
  • SynQuest Laboratories
  • 4-Methylphenylsulfonylurea
  • 250 mg
  • $ 149.00
  • SynQuest Laboratories
  • 4-Methylphenylsulfonylurea
  • 1 g
  • $ 425.00
  • SynQuest Laboratories
  • 4-Methylphenylsulfonylurea
  • 5 g
  • $ 1350.00
  • Medical Isotopes, Inc.
  • N-(p-Toluenesulfonyl)urea
  • 5 g
  • $ 610.00
  • Matrix Scientific
  • 4-Methylphenylsulfonylurea
  • 25g
  • $ 295.00
  • Matrix Scientific
  • 4-Methylphenylsulfonylurea
  • 5g
  • $ 95.00
  • Crysdot
  • N-Carbamoyl-4-methylbenzenesulfonamide 97%
  • 500g
  • $ 124.00
  • American Custom Chemicals Corporation
  • P-TOLYLSULFONGLUREA 95.00%
  • 25G
  • $ 584.85
Total 125 raw suppliers
Chemical Property of 4-Methylphenylsulfonylurea Edit
Chemical Property:
  • Appearance/Colour:white crystalline powder 
  • Melting Point:196-198 °C 
  • Refractive Index:1.579 
  • PKA:5.07±0.10(Predicted) 
  • PSA:97.64000 
  • Density:1.363 g/cm3 
  • LogP:2.52400 
  • Storage Temp.:Sealed in dry,Room Temperature 
  • Solubility.:DMSO (Slightly), Methanol (Slightly) 
  • Water Solubility.:777.9mg/L(37 oC) 
  • XLogP3:0.6
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:2
  • Exact Mass:214.04121336
  • Heavy Atom Count:14
  • Complexity:299
Purity/Quality:

99% *data from raw suppliers

N-(p-Toluenesulfonyl)urea *data from reagent suppliers

Safty Information:
  • Pictogram(s): Corrosive
  • Hazard Codes:
  • Statements: 34 
  • Safety Statements: 45-36/37/39-26 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC(=O)N
  • Uses 4-Methylphenylsulfonylurea can be used as pharmaceutical intermediate. 4-Methylphenylsulfonylurea is used in the synthesis of Glyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic agent. N-(p-Toluenesulfonyl)urea is used in the synthesis of Glyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic agent.
Technology Process of 4-Methylphenylsulfonylurea

There total 15 articles about 4-Methylphenylsulfonylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
p-toluenesulfonyl chloride; With sodium carbonate; sodium sulfite; In water; at 52 ℃; pH=7.2;
Azodicarboxamid; In water; at 81 ℃; Temperature; Reagent/catalyst; pH-value;
Guidance literature:
With ammonia; In toluene; at -5 - 5 ℃; for 4h; under 4500.45 Torr; Inert atmosphere; Large scale;
Guidance literature:
In ethanol; water; at 78 ℃; for 8h;
Refernces Edit
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