4-Methylphenylsulfonylurea

Base Information

Chemical Name:4-Methylphenylsulfonylurea
CAS No.:1694-06-0
Molecular Formula:C8H10N2O3S
Molecular Weight:214.245
Hs Code.:2935009090
European Community (EC) Number:216-900-3
UNII:Q9W3K7K5XB
DSSTox Substance ID:DTXSID90168704
Nikkaji Number:J60.111J
Wikidata:Q72495368
Mol file:1694-06-0.mol

Synonyms:4-tolylsulfonylurea;p-tolylsulfonylurea

Suppliers and Price of 4-Methylphenylsulfonylurea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(p-Toluenesulfonyl)urea
50g
$ 460.00

TCI Chemical
p-Toluenesulfonylurea >98.0%(HPLC)(T)
5g
$ 135.00

SynQuest Laboratories
4-Methylphenylsulfonylurea
250 mg
$ 149.00

SynQuest Laboratories
4-Methylphenylsulfonylurea
1 g
$ 425.00

SynQuest Laboratories
4-Methylphenylsulfonylurea
5 g
$ 1350.00

Medical Isotopes, Inc.
N-(p-Toluenesulfonyl)urea
5 g
$ 610.00

Matrix Scientific
4-Methylphenylsulfonylurea
25g
$ 295.00

Matrix Scientific
4-Methylphenylsulfonylurea
5g
$ 95.00

Crysdot
N-Carbamoyl-4-methylbenzenesulfonamide 97%
500g
$ 124.00

American Custom Chemicals Corporation
P-TOLYLSULFONGLUREA 95.00%
25G
$ 584.85

Total 117 raw suppliers

Chemical Property of 4-Methylphenylsulfonylurea

Chemical Property:

Appearance/Colour:white crystalline powder
Melting Point:196-198 °C
Refractive Index:1.579
PKA:5.07±0.10(Predicted)
PSA：97.64000
Density:1.363 g/cm³
LogP:2.52400
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly), Methanol (Slightly)
Water Solubility.:777.9mg/L(37 oC)
XLogP3:0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:214.04121336
Heavy Atom Count:14
Complexity:299

Purity/Quality:

99% ^*data from raw suppliers

N-(p-Toluenesulfonyl)urea ^*data from reagent suppliers

Safty Information:

Pictogram(s): C
Hazard Codes:C
Statements: 34
Safety Statements: 45-36/37/39-26

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC(=O)N
Uses 4-Methylphenylsulfonylurea can be used as pharmaceutical intermediate. 4-Methylphenylsulfonylurea is used in the synthesis of Glyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic agent. N-(p-Toluenesulfonyl)urea is used in the synthesis of Glyburide (G598350), a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic agent.

Technology Process of 4-Methylphenylsulfonylurea

There total 15 articles about 4-Methylphenylsulfonylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

: 123-77-3,97707-96-5
Azodicarboxamid

: 98-59-9
p-toluenesulfonyl chloride

: 1694-06-0
4-toluenesulfonylurea

Guidance literature:: p-toluenesulfonyl chloride; With sodium carbonate; sodium sulfite; In water; at 52 ℃; pH=7.2;

Azodicarboxamid; In water; at 81 ℃; Temperature; Reagent/catalyst; pH-value;