N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Base Information

Chemical Name:N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
CAS No.:582323-16-8
Molecular Formula:C11H6ClF2N3O
Molecular Weight:269.638
Hs Code.:
UNII:NCO5DC74G8
ChEMBL ID:CHEMBL2047521

Synonyms:582323-16-8;ICA 069673;ICA-069673;ICA069673;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;N-(2-chloropyrimidin-5-yl)-3,4-difluorobenzamide;NCO5DC74G8;CHEMBL2047521;N-(2-chloropyrimidin-5-yl)-3,4-difluoro-benzamide;ICA-69673;N-(2-chloro-pyrimidin-5-yl)-3,4-difluoro-benzamide;N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-benzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;UNII-NCO5DC74G8;C11H6ClF2N3O;SCHEMBL5343768;IIBSHMFXVWTQSJ-UHFFFAOYSA-N;BCP28988;BDBM50386291;HB1061;MFCD20926351;AKOS024458084;CS-6397;NCGC00387162-01;BS-17679;HY-101396;S0144;C75729;ICA-069673, >=98% (HPLC);A915129;N-(2-Chloro-5-pyrimidinyl)-3,4-difl uorobenzamide

Suppliers and Price of N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 15 raw suppliers

Chemical Property of N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:269.0167458
Heavy Atom Count:18
Complexity:300

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(=O)NC2=CN=C(N=C2)Cl)F)F

Technology Process of N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide

There total 3 articles about N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56621-90-0
2-chloro-5-aminopyrimidine

: 76903-88-3
3,4-difluorobenzoyl chloride

: 582323-16-8
ICA-069673

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ml200053x

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 582323-16-8
ICA-069673

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: pyridine / tetrahydrofuran / 1 h / 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml200053x