56621-90-0

Basic information

• Product Name: 5-Amino-2-chloropyrimidine
• Synonyms: 2-CHLOROPYRIMIDIN-5-AMINE;5-PYRIMIDINAMINE, 2-CHLORO-;5-AMINO-2-CHLOROPYRIMIDINE;2-Chloro-pyrimidin-5-ylamine;5-Pyrimidinamine, 2-chloro- (9CI);5-AMINO-2-CHLOROPYRIMIDINE,98%;5-Amino-2-chloropyrimidine ,97%;5-amine-2-Chloropyrimidine
• CAS NO: 56621-90-0
• Molecular Formula: C₄H₄ClN₃
• Molecular Weight: 129.55
• Product Categories: PYRIMIDINE;Amines;Pyrazines, Pyrimidines & Pyridazines;Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 56621-90-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 198-199℃
• Boiling Point: 338.8 °C at 760 mmHg
• Flash Point: 158.7 °C
• Appearance: Yellow to brown/Crystalline Powder or Solid
• Density: 1.437 g/cm³
• Refractive Index: 1.617
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -0.08±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-2-chloropyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-2-chloropyrimidine(56621-90-0)
• EPA Substance Registry System: 5-Amino-2-chloropyrimidine(56621-90-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-36/37/38
• Safety Statements: 26-36/37/39-22
• Hazardous Substances Data: 56621-90-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

Uses

5-Amino-2-chloropyrimidine is an aminopyrimidine derivative, a fibroblast growth factor receptor 4 inhibitor with anticancer activity.

InChI:InChI=1/C4H4ClN3/c5-4-7-1-3(6)2-8-4/h1-2H,6H2

Upstream product

• 3264-10-6 2-hydroxy-5-nitropyrimidine 
• 10320-42-0 2-Chloro-5-nitropyrimidine 

Downstream Products

• 1363333-06-5 5-amino-2-chloropyrimidine 
• 62802-43-1 5-dimethylamino-2-chloropyrimidine 
• 65735-68-4 2-morpholinopyrimidin-5-amine 
• 1426805-82-4 N-(2-chloropyrimidin-5-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide 
• 1027532-44-0 N-(2-chloropyrimidin-5-yl)benzamide 
• 582323-14-6 N-(2-chloropyrimidin-5-yl)-3-fluoro-4-methylbenzamide 
• 582323-10-2 N-(2-chloropyrimidin-5-yl)-3-fluorobenzamide 
• 582323-16-8 ICA-069673 
• 582323-12-4 N-(2-chloropyrimidin-5-yl)-3-trifluoromethylbenzamide 
• 582323-11-3 3-chloro-N-(2-chloropyrimidin-5-yl)-benzamide 
• 582323-13-5 4-chloro-N-(2-chloropyrimidin-5-yl)-3-fluorobenzamide 
• 4983-28-2 2-chloropyrimidine-5-ol 

Relevant articles and documents

Synthesis and tunable ion-recognition properties of novel macrocyclic triamides

In this work, we report synthesis of rigid macrocyclic triamides and their tunable ion-recognition properties as selective anion and metal receptors. Diphenylacetylene-containing cyclic triamide CTA-1b and three cyclic triamides bearing functional methoxy

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Orally Bioavailable Metal Chelators and Radical Scavengers: Multifunctional Antioxidants for the Coadjutant Treatment of Neurodegenerative Diseases

Neurodegenerative diseases are associated with oxidative stress that is induced by the presence of reactive oxygen species and the abnormal cellular accumulation of transition metals. Here, a new series of orally bioavailable multifunctional antioxidants (MFAO-2s) possessing a 2-diacetylamino-5-hydroxypyrimidine moiety is described. These MFAO-2s demonstrate both free radical and metal attenuating properties that are similar to the original published MFAO-1s that are based on 1-N,N′-dimethylsulfamoyl-1-4-(2-pyrimidyl)piperazine. Oral bioavailability studies in C57BL/6 mice demonstrate that the MFAO-2s accumulate in the brain at significantly higher levels than the MFAO-1s while achieving similar neural retina levels. The MFAO-2s protect human neuroblastoma and retinal pigmented epithelial cells against hydroxyl radicals in a dose-dependent manner by maintaining cell viability and intracellular glutathione levels. The MFAO-2s outperform clioquinol, a metal attenuator that has been investigated for the treatment of Alzheimer's disease.