7-Aminoquinolin-2(1H)-one

Base Information

• Chemical Name: 7-Aminoquinolin-2(1H)-one
• CAS No.: 58336-33-7
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933790090
• DSSTox Substance ID: DTXSID40596694
• Nikkaji Number: J89.973I
• Wikidata: Q82492011
• Mol file: 58336-33-7.mol

Synonyms:7-Aminoquinolin-2(1H)-one;58336-33-7;7-Amino-2(1H)-quinolinone;7-aminoquinolin-2-ol;7-amino-1H-quinolin-2-one;MFCD16660969;95833-14-0;7-amino-2-hydroxyquinoline;7-aminocarbostyril;7-amino-quinolone;7-Amino-2(1H)-quinolone;SCHEMBL1012563;DTXSID40596694;DXKZKYOSLNTYKH-UHFFFAOYSA-N;AKOS015854987;SB67904;AS-38311;SY025890;DB-100648;CS-0312338;A831834

Chemical Property of 7-Aminoquinolin-2(1H)-one

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 424.817oC at 760 mmHg
• Flash Point: 210.722oC
• PSA: 58.88000
• Density: 1.288g/cm3
• LogP: 1.69150
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 225

Purity/Quality:

98%min ^*data from raw suppliers

7-Aminoquinolin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC2=C1C=CC(=O)N2)N

Technology Process of 7-Aminoquinolin-2(1H)-one

There total 18 articles about 7-Aminoquinolin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

7-amino-3-chloro-3,4-dihydroquinolin-2(1H)-one (1116135-32-0) → 7-aminoquinolin-2(1H)-one (95833-14-0,58336-33-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 18h; Heating / reflux;

Reference yield:

7-nitroquinoline-2(1H)-one (75755-37-2) → 7-aminoquinolin-2(1H)-one (95833-14-0,58336-33-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 18h;

DOI:10.1021/acs.jmedchem.0c00982

Reference yield:

N-(2-oxo-1,2-dihydroquinolin-7-yl)acetamide → 7-aminoquinolin-2(1H)-one (95833-14-0,58336-33-7)

Guidance literature:

With hydrogenchloride; ethanol; Heating / reflux;

upstream raw materials:

7-nitrocarbostyril

4-amino-2-nitro-trans-cinnamic acid

2,4-dinitro-cinnamic acid

2,4-dinitrobenzaldehyde

Downstream raw materials:

quinoline-2,7-diol