75755-37-2

Basic information

• Product Name: 7-Nitroquinolin-2-ol
• Synonyms: 7-Nitroquinolin-2-ol;7-Nitroquinolin-2(1H)-one
• CAS NO: 75755-37-2
• Molecular Formula: C9H6N2O3
• Molecular Weight: 190.15554
• Mol File: 75755-37-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 7-Nitroquinolin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Nitroquinolin-2-ol(75755-37-2)
• EPA Substance Registry System: 7-Nitroquinolin-2-ol(75755-37-2)

Safety Data

• Hazardous Substances Data: 75755-37-2(Hazardous Substances Data)

Usage

General Description

7-Nitroquinolin-2-ol is a yellow crystalline solid that has several important chemical properties. It is a nitroaromatic compound with a quinoline ring structure and a hydroxyl group. This chemical can be used in the synthesis of various pharmaceuticals, dyes, and fluorescent markers. It is also commonly used as a reagent in analytical chemistry for the detection of metal ions such as copper, nickel, and other transition metals. Additionally, 7-Nitroquinolin-2-ol has been studied for its potential as an anti-cancer agent and as a photochemical probe for studying protein-DNA interactions. Its unique structure and properties make it a versatile and valuable chemical in various scientific and industrial applications.

Upstream product

• 14753-17-4 7-Nitro-chinolin-1-oxyd 
• 613-51-4 7-nitroquinoline 
• 30450-62-5 7-nitro-1,2,3,4-tetrahydro-quinoline 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 99-55-8 2-methyl-5-nitroaniline 
• 249604-78-2 2-ethoxy-7-nitroisoquinoline 
• 99-09-2 3-nitro-aniline 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 7664-93-9 sulfuric acid 
• 116557-35-8 2-amino-4-nitro-cinnamic acid 
• 1664-63-7 2-amino-cinnamic acid 

Downstream Products

• 95833-14-0 7-aminoquinolin-2(1H)-one 
• 49609-04-3 2-amino-7-nitroquinoline 
• 75755-33-8 7-nitro-2-quinoline 
• 75755-31-6 7-nitro-2-quinoline 
• 58336-33-7 7-amino-quinolin-2-ol 
• 49609-03-2 2-chloro-7-nitroquinoline 

Relevant articles and documents

Discovery of Benzopyridone-Based Transient Receptor Potential Vanilloid 1 Agonists and Antagonists and the Structural Elucidation of Their Activity Shift

Among a series of benzopyridone-based scaffolds investigated as human transient receptor potential vanilloid 1 (TRPV1) ligands, two isomeric benzopyridone scaffolds demonstrated a consistent and distinctive functional profile in which 2-oxo-1,2-dihydroquinolin-5-yl analogues (e.g., 2) displayed high affinity and potent antagonism, whereas 1-oxo-1,2-dihydroisoquinolin-5-yl analogues (e.g., 3) showed full agonism with high potency. Our computational models provide insight into the agonist-antagonist boundary of the analogues suggesting that the Arg557 residue in the S4-S5 linker might be important for sensing the agonist binding and transmitting signals. These results provide structural insights into the TRPV1 and the protein-ligand interactions at a molecular level.

Synthesis of 5- and 7-nitro-3-hydroxyquinolin-2-ones

A novel and efficient synthesis of 5- and 7-nitro-3-hydroxyquinolin-2-ones, from simple anilides, is presented, featuring the synthesis of the antibiotic agent viridicatin.