dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate

Base Information

• Chemical Name: dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate
• CAS No.: 6512-25-0
• Molecular Formula: C13H14 O8
• Molecular Weight: 298.249
• Mol file: 6512-25-0.mol

Synonyms:1,3-Benzenedicarboxylicacid, 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)-, dimethyl ester (9CI);Isophthalic acid, 4-(carboxymethyl)-2,6-dihydroxy-, trimethyl ester(6CI,7CI,8CI); NSC 146780

Chemical Property of dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate

Chemical Property:

• Vapor Pressure: 1.05E-07mmHg at 25°C
• Boiling Point: 421.6°Cat760mmHg
• Flash Point: 155.4°C
• Density: 1.387g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate

There total 7 articles about dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) → dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate (6512-25-0)

Guidance literature:

With sodium; at 120 ℃; for 2h; under 52.5053 Torr;

DOI:10.3390/molecules26113224

Reference yield: 52.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) → dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate (6512-25-0) + Dimethyl 2,4-dihydroxy-6-methylbenzene-1,3-dicarboxylate (15346-85-7)

Guidance literature:

3-oxopentanedioic acid dimethyl ester; With potassium carbonate; In dimethyl sulfoxide; at 60 - 70 ℃; for 5h;

With hydrogenchloride; water; In dimethyl sulfoxide;

DOI:10.1134/S1070428017060239

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) → dimethyl 2,4-dihydroxy-6-(2-methoxy-2-oxoethyl)benzene-1,3-dicarboxylate (6512-25-0) + Dimethyl 2-Hydroxy-4,6-diphenylisophthalate (35044-30-5)

Guidance literature:

With potassium hydroxide; 1,3-diphenylpropanedione; In methanol; for 72h; Heating;

DOI:10.1021/jo00167a054

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

dimethyl acetylmalonate

3-(Aminomethylen)-3,4-dihydro-1,2-benzoxathiin-4-on-2,2-dioxid

Downstream raw materials:

dimethyl 4-carboxy-3,5-dihydroxyhomophthalate

4-carboxy-3,5-dihydroxyphenylacetic acid

2-(3,5-dihydroxyphenyl)acetic acid

methyl 2-(3,5-dihydroxyphenyl)acetate

Refernces

• 1、 Ismailov,Ibragimova,Sadykhova,Mamedova,Yusubov. "Synthesis of functionally substituted furan and resorcinol derivatives from dimethyl 3-oxopentanedioate". . p. 950 - 952. Retrieved 2017/08/02.
• 2、 Takeuchi, Naoki,Sasaki, Yuki,Kosugi, Yoko,Tobinaga, Seisho. "Syntheses of Naturally Occuring 5-Carbonylmethyl-7-hydroxy-2-methyl-chromones and -chromanone (Studies on the β-Carbonyl Compounds Connected with the β-Polyketides. X)". . p. 2012 - 2015. Retrieved 2007/10/02.