2-Acetylmalonic acid dimethyl ester

Base Information

Chemical Name:2-Acetylmalonic acid dimethyl ester
CAS No.:17094-36-9
Molecular Formula:C7H10O5
Molecular Weight:174.15100
Hs Code.:
Mol file:17094-36-9.mol

Synonyms:acetone dicarboxylic dimethyl ester;dimethyl acetonedicarboxylate;Propanedioic acid, acetyl-, dimethyl ester;acetyl-malonic acid dimethyl ester;dimethyl C-acetylmalonate;dimethyl acetylmalonate;Acetylmalonsaeure-dimethylester;

Suppliers and Price of 2-Acetylmalonic acid dimethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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price

Total 1 raw suppliers

Chemical Property of 2-Acetylmalonic acid dimethyl ester

Chemical Property:

Melting Point:44 °C
Boiling Point:203.8±20.0 °C(Predicted)
PKA:8.03±0.46(Predicted)
PSA：69.67000
Density:1.172±0.06 g/cm3(Predicted)
LogP:-0.46240

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Acetylmalonic acid dimethyl ester

There total 6 articles about 2-Acetylmalonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-36-5
acetyl chloride

: 108-59-8
malonic acid dimethyl ester

: 17094-36-9
dimethyl acetylmalonate

: 113934-48-8
2-(1-Hydroxy-ethylidene)-malonic acid dimethyl ester

Guidance literature:: With triethylamine; magnesium chloride; In acetonitrile; at 0 - 25 ℃; for 23h; Overall yield = 96 %; Overall yield = 44.3 g; Inert atmosphere;
DOI:10.1021/ja506472u

Reference yield:

: 5781-53-3
monomethyl oxalyl chloride

: 6832-16-2
methyl diazoacetate

: 17094-36-9
dimethyl 3-diazo-2-oxosuccinate

Guidance literature:: In diethyl ether; for 2h;
DOI:10.1021/jo00222a047

Reference yield:

: 6773-29-1
dimethyl diazomalonate

: 17094-36-9
dimethyl acetylmalonate

Guidance literature:: Multi-step reaction with 2 steps

1: CuSO₄

2: 130 - 140 °C

With copper(II) sulfate;
DOI:10.1016/0040-4020(72)80112-1