Benzenesulfonamide, 4-[[6-bromo-1-oxo-3-(1-oxopropyl)-4-phenyl-2(1H)-isoquinolinyl]methyl]-

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Chemical Name:Benzenesulfonamide, 4-[[6-bromo-1-oxo-3-(1-oxopropyl)-4-phenyl-2(1H)-isoquinolinyl]methyl]-
CAS No.:583836-63-9
Molecular Formula:C25H21BrN2O4S
Molecular Weight:525.423
Hs Code.:

Synonyms:

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Chemical Property of Benzenesulfonamide, 4-[[6-bromo-1-oxo-3-(1-oxopropyl)-4-phenyl-2(1H)-isoquinolinyl]methyl]-

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Technology Process of Benzenesulfonamide, 4-[[6-bromo-1-oxo-3-(1-oxopropyl)-4-phenyl-2(1H)-isoquinolinyl]methyl]-

There total 4 articles about Benzenesulfonamide, 4-[[6-bromo-1-oxo-3-(1-oxopropyl)-4-phenyl-2(1H)-isoquinolinyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 4-[(2-hydroxybutylamino)methyl]benzenesulfonamide

: 412299-83-3
4-bromo-2-(phenylcarbonyl)benzoic acid

: 583836-63-9
4-(6-bromo-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzenesulfonamide

Guidance literature:: 4-[(2-hydroxybutylamino)methyl]benzenesulfonamide; 4-bromo-2-(phenylcarbonyl)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 15h;

With tetra-n-propylammonium perruthenate.; 4-methylmorpholine N-oxide; In dichloromethane; at 0 - 20 ℃; for 3h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; for 12h; Heating / reflux;

Reference yield:

: 138-37-4
mafenide hydrochloride

: 583836-63-9
4-(6-bromo-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; methanol / 12 h / Heating / reflux

1.2: 2 h / 20 °C

1.3: 0.5 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 15 h / 20 °C

2.2: 3 h / 0 - 20 °C

2.3: 12 h / Heating / reflux

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide);

Reference yield:

: 86-90-8
4-bromophthalic anhydride

: 583836-63-9
4-(6-bromo-1-oxo-4-phenyl-3-propionyl-1H-isoquinolin-2-ylmethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1.5 h / 20 °C / Heating / reflux

1.2: 0.5 h / 20 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 15 h / 20 °C

2.2: 3 h / 0 - 20 °C

2.3: 12 h / Heating / reflux

With aluminum (III) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide);