2,5,6-trichloronicotinoyl chloride

Base Information

• Chemical Name: 2,5,6-trichloronicotinoyl chloride
• CAS No.: 58584-88-6
• Molecular Formula: C6HCl4NO
• Molecular Weight: 244.89000
• Hs Code.: 2933399090
• Mol file: 58584-88-6.mol

Synonyms:2,5,6-Trichlor-nicotinoylchlorid;2,5,6-trichloro-pyridine-3-carboxylic acid chloride;2,5,6-trichloro-nicotinoyl chloride;2,5,6-Trichloronicotinamide;2,5,6-trichloro-pyridine-3-carboxamide;2,5,6-Trichlorpyridin-3-carbonsaeurechlorid;3-Pyridinecarboxamide,2,5,6-trichloro;

Chemical Property of 2,5,6-trichloronicotinoyl chloride

Chemical Property:

• Melting Point: 38-39 °C
• Boiling Point: 87-88 °C(Press: 0.15 Torr)
• PKA: -6.58±0.10(Predicted)
• PSA: 29.96000
• Density: 1.689±0.06 g/cm3(Predicted)
• LogP: 3.42080

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5,6-trichloronicotinoyl chloride

There total 6 articles about 2,5,6-trichloronicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,5,6-Trichloronicotinic Acid (54718-39-7) → 2,5,6-trichloro-pyridine-3-carboxylic acid chloride (58584-88-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

2,5,6-trichloro-3-chloromethylpyridine (52465-59-5) → 2,5,6-trichloro-pyridine-3-carboxylic acid chloride (58584-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: HgNO₃; CuSO₄*5H₂O; HNO₃ / H₂SO₄

2: 81 percent / SOCl₂ / benzene; dimethylformamide / 2.5 h / Heating

With thionyl chloride; mercurous nitrate; nitric acid; copper(II) sulfate; In sulfuric acid; N,N-dimethyl-formamide; benzene;

DOI:10.1016/S0968-0896(02)00022-6

Reference yield:

3-methyl-piperidine-2,6-dione (29553-51-3) → 2,5,6-trichloro-pyridine-3-carboxylic acid chloride (58584-88-6)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus pentachloride / 150 °C

2: hydrogenchloride; potassium permanganate / water / 48 h

3: oxalyl dichloride / dichloromethane

With hydrogenchloride; potassium permanganate; oxalyl dichloride; phosphorus pentachloride; In dichloromethane; water;

DOI:10.1016/j.bmcl.2011.03.053

upstream raw materials:

2,5,6-Trichloronicotinic Acid

2,5,6-trichloro-3-chloromethylpyridine

3-methyl-piperidine-2,6-dione

2,5,6-trichloro-3-methylpyridine