4-Piperidinol, 4-methyl-, hydrochloride (1:1)

Base Information

• Chemical Name: 4-Piperidinol, 4-methyl-, hydrochloride (1:1)
• CAS No.: 586375-35-1
• Molecular Formula: C6H13NO.ClH
• Molecular Weight: 151.636
• Hs Code.: 2933399090
• Mol file: 586375-35-1.mol

Synonyms:4-methylpiperidin-4-ol,hydrochloride;

Chemical Property of 4-Piperidinol, 4-methyl-, hydrochloride (1:1)

Chemical Property:

• PSA: 32.26000
• LogP: 1.25160

Purity/Quality:

99%, ^*data from raw suppliers

4-Methylpiperidin-4-olHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidinol, 4-methyl-, hydrochloride (1:1)

There total 1 articles about 4-Piperidinol, 4-methyl-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 4-methylpiperidin-4-ol hydrochloride (586375-35-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 14 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 20 °C

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol;

Reference yield: 75.0%

4-methylpiperidin-4-ol hydrochloride (586375-35-1) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-methyl-1-(4-nitrophenyl)piperidin-4-ol (1002726-90-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 2.5h; Reflux;

DOI:10.1021/jm500228a

Reference yield: 71.0%

4-methylpiperidin-4-ol hydrochloride (586375-35-1) + N-(2-formyl-7-methyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide (1314128-51-2) → N-{2-[(4-hydroxy-4-methylpiperidin-1-yl)methyl]-7-methyl-1H-indol-6-yl}-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide (1314127-52-0)

Guidance literature:

4-methylpiperidin-4-ol hydrochloride; N-(2-formyl-7-methyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide; With acetic acid; triethylamine; In ISOPROPYLAMIDE; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In ISOPROPYLAMIDE; at 20 ℃; for 20h;

With sodium hydroxide; In ISOPROPYLAMIDE; water; at 0 ℃;

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

Downstream raw materials:

3-bromo-4-[(2,4-difluorobenzyl)oxy]-1{4-[(4-hydroxy-4-methylpiperidin-1-yl)carbonyl]benzyl}-6-methylpyridin-2(1H)-one

tert-butyl 4-hydroxy-4-methylpiperidine-1-carboxylate

4-(4-fluoro-3-(4-hydroxy-4-methylpiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one

1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)-4-methylpiperidin-4-ol

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