7-fluoro-1H-indole-4-carboxylic Acid

Base Information

Chemical Name:7-fluoro-1H-indole-4-carboxylic Acid
CAS No.:588688-52-2
Molecular Formula:C9H6FNO2
Molecular Weight:179.14800
Hs Code.:
European Community (EC) Number:840-716-8
Nikkaji Number:J2.345.480G
Mol file:588688-52-2.mol

Synonyms:7-fluoro-1H-indole-4-carboxylic Acid;588688-52-2;1H-INDOLE-4-CARBOXYLIC ACID,7-FLUORO;1H-Indole-4-carboxylic acid, 7-fluoro-;SCHEMBL21818677;7-Fluoroindole-4-carboxylic Acid;AKOS025149676;CS-0055941;FT-0765983;D87694;EN300-1608560

Suppliers and Price of 7-fluoro-1H-indole-4-carboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
1H-INDOLE-4-CARBOXYLICACID,7-FLUORO 95
500mg
$ 668.00

American Custom Chemicals Corporation
7-FLUORO-1H-INDOLE-4-CARBOXYLIC ACID 95.00%
5MG
$ 500.23

Total 7 raw suppliers

Chemical Property of 7-fluoro-1H-indole-4-carboxylic Acid

Chemical Property:

PSA：53.09000
LogP:2.00520
XLogP3:1.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:179.03825660
Heavy Atom Count:13
Complexity:222

Purity/Quality:

NLT 98% ^*data from raw suppliers

1H-INDOLE-4-CARBOXYLICACID,7-FLUORO 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C2C(=C1C(=O)O)C=CN2)F

Technology Process of 7-fluoro-1H-indole-4-carboxylic Acid

There total 2 articles about 7-fluoro-1H-indole-4-carboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 883500-66-1
4-bromo-7-fluoro-1H-indole

: 124-38-9,18923-20-1
carbon dioxide

: 588688-52-2
7-fluoroindole-4-carboxylic acid

Guidance literature:: 4-bromo-7-fluoro-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; hexane; cooling;
DOI:10.1002/ejoc.200600118

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 588688-52-2
7-fluoroindole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 34 percent / tetrahydrofuran / -40 °C

2.1: BuLi / hexane; tetrahydrofuran / 2 h / -75 °C

2.2: 68 percent / hexane; tetrahydrofuran / cooling

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1002/ejoc.200600118