2-Cyclohexen-1-ol, 6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-, 1-benzoate, (1S,4R,5E,6R)-

Base Information

Chemical Name:2-Cyclohexen-1-ol, 6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-, 1-benzoate, (1S,4R,5E,6R)-
CAS No.:588693-67-8
Molecular Formula:C45H52O8Si
Molecular Weight:748.989
Hs Code.:

2-Cyclohexen-1-ol,
6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil
yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-,
1-benzoate, (1S,4R,5E,6R)-

Synonyms:

Suppliers and Price of 2-Cyclohexen-1-ol, 6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-, 1-benzoate, (1S,4R,5E,6R)-

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Chemical Property of 2-Cyclohexen-1-ol, 6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-, 1-benzoate, (1S,4R,5E,6R)-

Chemical Property:

Purity/Quality:

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Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Cyclohexen-1-ol, 6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-, 1-benzoate, (1S,4R,5E,6R)-

There total 7 articles about 2-Cyclohexen-1-ol, 6-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-[[[(1,1-dimethylethyl)diphenylsil yl]oxy]methyl]-5-(2-hydroxyethylidene)-4-[(phenylmethoxy)methoxy]-, 1-benzoate, (1S,4R,5E,6R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: Benzoic acid (1S,4R,6S)-4-benzyloxymethoxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-((S)-1,2-dihydroxy-ethyl)-5-[2-hydroxy-eth-(E)-ylidene]-cyclohex-2-enyl ester

: 588693-67-8
Benzoic acid (1S,4R,6R)-4-benzyloxymethoxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-[2-hydroxy-eth-(E)-ylidene]-cyclohex-2-enyl ester

Guidance literature:: 2,2-dimethoxy-propane; Benzoic acid (1S,4R,6S)-4-benzyloxymethoxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-((S)-1,2-dihydroxy-ethyl)-5-[2-hydroxy-eth-(E)-ylidene]-cyclohex-2-enyl ester; With 10-camphorsufonic acid; In acetone; at 20 ℃; for 0.666667h;

With methanol; pyridinium p-toluenesulfonate; at 20 ℃; for 0.0833333h;
DOI:10.1021/ja0342998

Reference yield:

: Benzoic acid (1S,5R,8S,8aR)-5-benzyloxymethoxy-7-(tert-butyl-diphenyl-silanyloxymethyl)-1-hydroxymethyl-3-methoxy-3,5,8,8a-tetrahydro-1H-isochromen-8-yl ester

: 588693-67-8
Benzoic acid (1S,4R,6R)-4-benzyloxymethoxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-[2-hydroxy-eth-(E)-ylidene]-cyclohex-2-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 12.80 g / DMAP / pyridine / 3 h / 20 °C

2.1: 1.60 g / aq. PPTS; HgO / acetone / 7 h / 55 °C

3.1: Mg(OEt)2 / methanol; ethyl acetate / 1 h / 20 °C

4.1: NaBH₄ / methanol / 0.25 h / 20 °C

5.1: (+/-)-CSA / acetone / 0.67 h / 20 °C

5.2: 6.88 g / PPTS; MeOH / 0.08 h / 20 °C

With dmap; sodium tetrahydroborate; 10-camphorsufonic acid; magnesium ethylate; pyridinium p-toluenesulfonate; mercury(II) oxide; In pyridine; methanol; ethyl acetate; acetone;
DOI:10.1021/ja0342998

Reference yield:

: 588693-55-4
benzoic acid 1-(tert-butyl-dimethyl-silanyloxymethyl)-7-(tert-butyl-diphenyl-silanyloxymethyl)-5-hydroxy-3-methoxy-3,5,8,8a-tetrahydro-1H-isochromen-8-yl ester

: 588693-67-8
Benzoic acid (1S,4R,6R)-4-benzyloxymethoxy-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-5-[2-hydroxy-eth-(E)-ylidene]-cyclohex-2-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: i-Pr₂NEt; DMAP / 1,2-dichloro-ethane / 4 h / 60 °C

2.1: (+/-)-CSA; MeOH / 1 h / 20 °C

3.1: 12.80 g / DMAP / pyridine / 3 h / 20 °C

4.1: 1.60 g / aq. PPTS; HgO / acetone / 7 h / 55 °C

5.1: Mg(OEt)2 / methanol; ethyl acetate / 1 h / 20 °C

6.1: NaBH₄ / methanol / 0.25 h / 20 °C

7.1: (+/-)-CSA / acetone / 0.67 h / 20 °C

7.2: 6.88 g / PPTS; MeOH / 0.08 h / 20 °C

With methanol; dmap; sodium tetrahydroborate; 10-camphorsufonic acid; magnesium ethylate; pyridinium p-toluenesulfonate; N-ethyl-N,N-diisopropylamine; mercury(II) oxide; In pyridine; methanol; ethyl acetate; 1,2-dichloro-ethane; acetone;
DOI:10.1021/ja0342998