Acetamide, 2,2'-[1,2-phenylenebis(oxy)]bis[N-phenyl-

Base Information

• Chemical Name: Acetamide, 2,2'-[1,2-phenylenebis(oxy)]bis[N-phenyl-
• CAS No.: 59007-19-1
• Molecular Formula: C22H20N2O4
• Molecular Weight: 376.412
• DSSTox Substance ID: DTXSID50440912
• Nikkaji Number: J1.849.328D
• Wikidata: Q82257409
• Mol file: 59007-19-1.mol

Synonyms:59007-19-1;Acetamide, 2,2'-[1,2-phenylenebis(oxy)]bis[N-phenyl-;DTXSID50440912;2,2'-(1,2-Phenylenebisoxy)bis(N-phenylacetamide)

Chemical Property of Acetamide, 2,2'-[1,2-phenylenebis(oxy)]bis[N-phenyl-

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 376.14230712
• Heavy Atom Count: 28
• Complexity: 443

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)COC2=CC=CC=C2OCC(=O)NC3=CC=CC=C3

Technology Process of Acetamide, 2,2'-[1,2-phenylenebis(oxy)]bis[N-phenyl-

There total 5 articles about Acetamide, 2,2'-[1,2-phenylenebis(oxy)]bis[N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[2-(2-chloro-2-oxoethoxy)phenoxy]acetyl chloride (31250-16-5) + aniline (62-53-3) → N,N'-Diphenyl-1,2-phenylenedioxydiacetamide (59007-19-1)

Guidance literature:

With PEG-400; sodium hydroxide; In dichloromethane; water; for 1h; Ambient temperature;

DOI:10.1080/00397919608004594

Reference yield:

2-[2-(2-hydroxy-2-oxoethoxy)phenoxy]acetic acid (5411-14-3) → N,N'-Diphenyl-1,2-phenylenedioxydiacetamide (59007-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / SOCl₂ / 6 h / Heating

2: 98 percent / PEG-400, NaOH / H₂O; CH₂Cl₂ / 1 h / Ambient temperature

With PEG-400; sodium hydroxide; thionyl chloride; In dichloromethane; water;

DOI:10.1080/00397919608004594

Reference yield:

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) → N,N'-Diphenyl-1,2-phenylenedioxydiacetamide (59007-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / 90 °C

2: 94 percent / SOCl₂ / 6 h / Heating

3: 98 percent / PEG-400, NaOH / H₂O; CH₂Cl₂ / 1 h / Ambient temperature

With PEG-400; sodium hydroxide; thionyl chloride; In dichloromethane; water;

DOI:10.1080/00397919608004594

upstream raw materials:

2-[2-(2-hydroxy-2-oxoethoxy)phenoxy]acetic acid

aniline

[2-(2-chloro-2-oxoethoxy)phenoxy]acetyl chloride

benzene-1,2-diol