2-BroMo-4-trifluoroMethyl-3-quinolinecarboxylic acid

Base Information

• Chemical Name: 2-BroMo-4-trifluoroMethyl-3-quinolinecarboxylic acid
• CAS No.: 590372-20-6
• Molecular Formula: C11H5BrF3NO2
• Molecular Weight: 320.06200
• Hs Code.: 2933499090
• Mol file: 590372-20-6.mol

Synonyms:2-bromo-4-trifluoromethyl-3-quinolinecarboxylic acid;2-Bromo 4-(trifluoromethyl)quinoline-3-carboxylic acid;

Chemical Property of 2-BroMo-4-trifluoroMethyl-3-quinolinecarboxylic acid

Chemical Property:

• PSA: 50.19000
• LogP: 3.71430
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo4-(trifluoromethyl)quinoline-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-4-trifluoroMethyl-3-quinolinecarboxylic acid

There total 3 articles about 2-BroMo-4-trifluoroMethyl-3-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

carbon dioxide (124-38-9,18923-20-1) + 2-bromo-4-(trifluoromethyl)quinoline (590372-17-1) → 2-bromo-4-trifluoromethyl-3-quinolinecarboxylic acid (590372-20-6)

Guidance literature:

2-bromo-4-(trifluoromethyl)quinoline; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; Further stages.;

DOI:10.1002/ejoc.200200633

Reference yield:

aniline (62-53-3) → 2-bromo-4-trifluoromethyl-3-quinolinecarboxylic acid (590372-20-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.75 h / 110 °C

1.2: 34 percent / sulfuric acid; water / 0.75 h / 90 °C

2.1: 66 percent / phosphorus oxybromide / 2 h / 140 °C

3.1: 81 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C

With n-butyllithium; diisopropylamine; phosphorus(V) oxybromide; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.200200633

Reference yield:

4-(trifluoromethyl)quinolin-2(1H)-one (25199-84-2) → 2-bromo-4-trifluoromethyl-3-quinolinecarboxylic acid (590372-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / phosphorus oxybromide / 2 h / 140 °C

2: 81 percent / diisopropylamine; butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C

With n-butyllithium; diisopropylamine; phosphorus(V) oxybromide; In tetrahydrofuran; hexane;

DOI:10.1002/ejoc.200200633

upstream raw materials:

carbon dioxide

2-bromo-4-(trifluoromethyl)quinoline

aniline

4-(trifluoromethyl)quinolin-2(1H)-one

Downstream raw materials:

4-trifluoromethyl-3-quinolinecarboxylic acid

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