2,4-Dichloro-6-ethylpyrimidine

Base Information

• Chemical Name: 2,4-Dichloro-6-ethylpyrimidine
• CAS No.: 6554-65-0
• Molecular Formula: C6H6Cl2N2
• Molecular Weight: 177.033
• Hs Code.: 2933599090
• European Community (EC) Number: 844-844-5
• NSC Number: 58568
• DSSTox Substance ID: DTXSID40289014
• Wikidata: Q82026163
• Mol file: 6554-65-0.mol

Synonyms:2,4-dichloro-6-ethylpyrimidine;6554-65-0;Pyrimidine, 2,4-dichloro-6-ethyl-;2,4-Dichloro-6-ethyl-Pyrimidine;NSC58568;SCHEMBL1762646;6-ethyl-2,4-dichloropyrimidine;DTXSID40289014;BCP21652;NSC 58568;NSC-58568;AKOS015830916;SB56461;AS-83153;CS-0182540;FT-0702996;EN300-85806;A19023;E80489;Z1238571436

Chemical Property of 2,4-Dichloro-6-ethylpyrimidine

Chemical Property:

• Vapor Pressure: 0.0447mmHg at 25°C
• Boiling Point: 245.5°Cat760mmHg
• PKA: -2.17±0.30(Predicted)
• Flash Point: 126°C
• PSA: 25.78000
• Density: 1.335g/cm³
• LogP: 2.34580
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 175.9908036
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dichloro-6-ethylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=CC(=NC(=N1)Cl)Cl

Technology Process of 2,4-Dichloro-6-ethylpyrimidine

There total 3 articles about 2,4-Dichloro-6-ethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.7%

→ 2,4-dichloro-6-ethylpyrimidine (6554-65-0) + 6-methyl-2-(2-methyl-4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride

Guidance literature:

Reference yield:

→ 2,4-dichloro-6-ethylpyrimidine (6554-65-0) + trichlorophosphate (10025-87-3,12599-09-6,63736-95-8,39380-77-3)

Guidance literature:

Reference yield:

ethyl butyroyl acetate (3249-68-1) → 2,4-dichloro-6-ethylpyrimidine (6554-65-0) + 2,6-dichloro-4-n-propyl-pyrimidine (89938-07-8)

Guidance literature:

With sodium methylate; thiourea; In ethanol;

upstream raw materials:

ethyl butyroyl acetate

Downstream raw materials:

4-chloro-6-ethylpyrimidine

6-ethylpyrimidin-4-amine

Refernces