2,4-Dichloro-6-propylpyrimidine

Base Information

• Chemical Name: 2,4-Dichloro-6-propylpyrimidine
• CAS No.: 89938-07-8
• Molecular Formula: C7H8Cl2N2
• Molecular Weight: 191.06
• Hs Code.: 2933599090
• NSC Number: 58569
• DSSTox Substance ID: DTXSID00289015
• Wikidata: Q82026164
• Mol file: 89938-07-8.mol

Synonyms:2,4-dichloro-6-propylpyrimidine;89938-07-8;2,6-dichloro-4-n-propylpyrimidine;NSC58569;2,4-DICHLORO-6-PROPYL-PYRIMIDINE;SCHEMBL5672114;DTXSID00289015;XUJXLDZCRUCDJC-UHFFFAOYSA-N;NSC-58569;AKOS015946473;SB56477;CS-0235329;FT-0708264;EN300-155309;Z1216824384

Chemical Property of 2,4-Dichloro-6-propylpyrimidine

Chemical Property:

• Vapor Pressure: 0.0184mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 261.8 °C at 760 mmHg
• PKA: -2.12±0.30(Predicted)
• Flash Point: 137.5 °C
• PSA: 25.78000
• Density: 1.281 g/cm³
• LogP: 2.73590
• Storage Temp.: 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 190.0064537
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

2,4-dichloro-6-propylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCC1=CC(=NC(=N1)Cl)Cl

Technology Process of 2,4-Dichloro-6-propylpyrimidine

There total 5 articles about 2,4-Dichloro-6-propylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

propylthiouracil (51-52-5) → 2,6-dichloro-4-n-propyl-pyrimidine (89938-07-8)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

ethyl butyroyl acetate (3249-68-1) → 2,4-dichloro-6-ethylpyrimidine (6554-65-0) + 2,6-dichloro-4-n-propyl-pyrimidine (89938-07-8)

Guidance literature:

With sodium methylate; thiourea; In ethanol;

Reference yield:

6-propyl(1H,3H)pyrimidine-2,4-dione (13345-08-9) → 2,6-dichloro-4-n-propyl-pyrimidine (89938-07-8)

Guidance literature:

With trichlorophosphate; for 1.5h; Heating;

DOI:10.1021/jm00179a012

upstream raw materials:

6-propyl(1H,3H)pyrimidine-2,4-dione

2,6-Dichloropyrimidine

propyllithium

propylthiouracil

Downstream raw materials:

4-(2,4-Diamino-6-propyl-pyrimidin-5-ylmethyl)-2,6-dimethoxy-phenol

6-Propyl-5-(3,4,5-trimethoxy-benzyl)-pyrimidine-2,4-diamine

(R)-N-{1-[2-(3-cyanophenylamino)-6-propylpyrimidin-4-yl]piperidin-3-yl}acetamide hydrochloride

N₄,N₄-diethyl-N₂-(4-methoxyphenyl)-6-propylpyrimidine-2,4-diamine