4,5-dimethylquinoline

Base Information

• Chemical Name: 4,5-dimethylquinoline
• CAS No.: 59129-74-7
• Molecular Formula: C11H11N
• Molecular Weight: 157.215
• Mol file: 59129-74-7.mol

Synonyms:

Chemical Property of 4,5-dimethylquinoline

Chemical Property:

• Vapor Pressure: 0.00529mmHg at 25°C
• Melting Point: 78°C
• Refractive Index: 1.6105 (estimate)
• Boiling Point: 266.88°C (estimate)
• PSA: 0.00000
• Density: 1.0491 (estimate)
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dimethylquinoline

There total 2 articles about 4,5-dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-amino-3-methylbenzene (108-44-1) → 4,7-dimethylquinoline (40941-54-6) + 4,5-dimethylquinoline (59129-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; oxygen; palladium diacetate; sodium acetate / toluene / 80 °C / 760.05 Torr / Inert atmosphere; Schlenk technique

2: iron(III) chloride hexahydrate / ethanol / Inert atmosphere; Schlenk technique

With iron(III) chloride hexahydrate; oxygen; sodium acetate; palladium diacetate; acetic acid; In ethanol; toluene;

DOI:10.1021/acs.joc.8b00287

Reference yield:

4-[(3-methylphenyl)amino]butan-2-one (1179812-15-7) → 4,7-dimethylquinoline (40941-54-6) + 4,5-dimethylquinoline (59129-74-7)

Guidance literature:

With iron(III) chloride hexahydrate; In ethanol; Overall yield = 18 mg; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.joc.8b00287

upstream raw materials:

1-amino-3-methylbenzene

4-[(3-methylphenyl)amino]butan-2-one