Diethyl 2-(4-fluorobenzyl)malonate

Base Information

Chemical Name:Diethyl 2-(4-fluorobenzyl)malonate
CAS No.:59223-74-4
Molecular Formula:C14H17FO4
Molecular Weight:268.285
Hs Code.:
DSSTox Substance ID:DTXSID00472485
Wikidata:Q82301451

Synonyms:diethyl 2-(4-fluorobenzyl)malonate;59223-74-4;Diethyl 2-[(4-fluorophenyl)methyl]propanedioate;SCHEMBL7436472;DTXSID00472485;AKOS017549409;Diethyl 2-[(4-fluorophenyl)methyl] malonate;Diethyl [(4-fluorophenyl)methyl]propanedioate;A1-47765

Suppliers and Price of Diethyl 2-(4-fluorobenzyl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Diethyl 2-(4-fluorobenzyl)malonate

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:268.11108718
Heavy Atom Count:19
Complexity:280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CC1=CC=C(C=C1)F)C(=O)OCC

Technology Process of Diethyl 2-(4-fluorobenzyl)malonate

There total 6 articles about Diethyl 2-(4-fluorobenzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 790-53-4
diethyl 2-(4-fluorobenzylidene)malonate

: 59223-74-4
1,3-diethyl 2-[(4-fluorophenyl)methyl]propanedioate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; tris(2,4,6-trifluorophenyl)borane triethylphosphine oxide; at 50 ℃; for 24h; under 3750.38 Torr; Inert atmosphere;
DOI:10.1002/chem.201301158

Reference yield: 53.0%

: 459-46-1
4-Fluorobenzyl bromide

: 105-53-3
diethyl malonate

: 59223-74-4
1,3-diethyl 2-[(4-fluorophenyl)methyl]propanedioate

Guidance literature:: diethyl malonate; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h;

4-Fluorobenzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/adsc.201800956