Z-PRO-GLY-OH

Base Information

• Chemical Name: Z-PRO-GLY-OH
• CAS No.: 2766-18-9
• Molecular Formula: C15H18 N2 O5
• Molecular Weight: 306.318
• Hs Code.: 2933990090
• Mol file: 2766-18-9.mol

Synonyms:1-Pyrrolidinecarboxylicacid, 2-[(carboxymethyl)carbamoyl]-, 1-benzyl ester, L- (8CI);1-Pyrrolidinecarboxylic acid, L-2-[(carboxymethyl)carbamoyl]-, 1-benzyl ester(6CI); Glycine, N-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-;N-Benzyloxycarbonyl-L-prolylglycine; NSC 334028

Chemical Property of Z-PRO-GLY-OH

Chemical Property:

• Vapor Pressure: 1.45E-14mmHg at 25°C
• Boiling Point: 585.8°Cat760mmHg
• Flash Point: 308.1°C
• PSA: 95.94000
• Density: 1.335g/cm³
• LogP: 1.31720
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Z-Pro-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-PRO-GLY-OH

There total 8 articles about Z-PRO-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl chloroformate (501-53-1,94274-21-2) + N-prolylglycine (2578-57-6) → N-carbobenzoxyprolylglycine (2766-18-9)

Guidance literature:

With potassium carbonate; In water;

DOI:10.1016/j.ejps.2004.09.006

Reference yield: 76.0%

ethyl (N-benzoxycarbonyl-L-prolyl)glycinate (2766-31-6) → N-carbobenzoxyprolylglycine (2766-18-9)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In acetone; for 2h;

DOI:10.1007/BF02219346

Reference yield: 54.0%

Z-L-Pro-Gly-OBzl (7536-45-0) → N-carbobenzoxyprolylglycine (2766-18-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1246/bcsj.57.103

upstream raw materials:

ethyl (N-benzoxycarbonyl-L-prolyl)glycinate

Z-L-Pro-Gly-OBzl

benzyl chloroformate

N-prolylglycine

Downstream raw materials:

N-[N-(1-benzyloxycarbonyl-L-prolyl)-glycyl]-L-phenylalanine-methyl ester

trans-1-[N-(1-benzyloxycarbonyl-L-prolyl)-glycyl]-4-hydroxy-L-proline-methyl ester

trans-1-[N-(1-benzyloxycarbonyl-L-prolyl)-glycyl=>4-hydroxy-L-proline-benzyl ester

N-prolylglycine

Refernces

• 1、 Kon, Kazumasa,Kohari, Yoshihito,Murata, Miki. "Unnatural tripeptide as highly enantioselective organocatalyst for asymmetric aldol reaction of isatins". . p. 415 - 418. Retrieved 2019/01/05.
• 2、 Chen,Sung,Sung, Kuangsen. "Synthesis of proline-derived dipeptides and their catalytic enantioselective direct aldol reactions: Catalyst, solvent, additive and temperature effects". experimental part. p. 839 - 845. Retrieved 2010/08/06.