Pro-Gly

Base Information

• Chemical Name: Pro-Gly
• CAS No.: 2578-57-6
• Molecular Formula: C7H12N2O3
• Molecular Weight: 172.184
• Hs Code.: 2933990090
• NSC Number: 89175
• Mol file: 2578-57-6.mol

Synonyms:L-prolylglycine;Pro-Gly;prolylglycine

Chemical Property of Pro-Gly

Chemical Property:

• Appearance/Colour: White to off white powder
• Vapor Pressure: 4.5E-10mmHg at 25°C
• Melting Point: 236℃
• Refractive Index: 1.511
• Boiling Point: 468.5 °C at 760 mmHg
• Flash Point: 237.1 °C
• PSA: 78.43000
• Density: 1.266 g/cm³
• LogP: -0.34110
• Storage Temp.: −20°C
• XLogP3: -3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 172.08479225
• Heavy Atom Count: 12
• Complexity: 193

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-Pro-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(NC1)C(=O)NCC(=O)O
• Uses: Substrate for prolinase (prolyl dipeptidase).

Technology Process of Pro-Gly

There total 20 articles about Pro-Gly which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-tert-butyloxycarbonyl-L-prolylglycine (51785-82-1,250290-80-3) → N-prolylglycine (2578-57-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 95.0%

N-carbobenzoxyprolylglycine (2766-18-9) → N-prolylglycine (2578-57-6)

Guidance literature:

With hydrogen; 10% palladium on active carbon; In methanol; water;

DOI:10.1007/BF02219346

Reference yield: 93.0%

→ N-prolylglycine (2578-57-6)

Guidance literature:

With dimethyl ether-poly(hydrogen fluoride); at 0 ℃; for 1h;

upstream raw materials:

(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

N-carbobenzoxyprolylglycine

N-(1-trifluoroacetyl-L-prolyl)-glycine ethyl ester

N-tert-butyloxycarbonyl-L-prolylglycine

Downstream raw materials:

N-[1-(N-benzyloxycarbonyl-glycyl)-L-prolyl]-glycine

(S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

N,O-bis-CBZ-5-amino-N-(hydroxymethyl)pentanamide

piperidin-2-one

Refernces

• 1、 Zhang, Liang,Li, Feng,Hou, Chenhui,Zhu, Sifeng,Zhong, Lili,Zhao, Jianchun,Song, Cai,Li, Wenbao. "Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke". . p. 2529 - 2542. Retrieved 2020/05/25.
• 2、 Furukawa, Shinya,Fukuyama, Takahide,Matsui, Akihiro,Kuratsu, Mai,Nakaya, Ryotaro,Ineyama, Takashi,Ueda, Hiroshi,Ryu, Ilhyong. "Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids". supporting information. p. 11980 - 11983. Retrieved 2015/08/18.