Benzoic acid, 2-[[4-[2-(acetylamino)-3-[[(4-chlorophenyl)methyl]amino]-3-oxopropyl]-2- ethylphenyl][(1,1-dimethylethoxy)oxoacetyl]amino]-, diphenylmethyl ester

Base Information

Chemical Name:Benzoic acid, 2-[[4-[2-(acetylamino)-3-[[(4-chlorophenyl)methyl]amino]-3-oxopropyl]-2- ethylphenyl][(1,1-dimethylethoxy)oxoacetyl]amino]-, diphenylmethyl ester
CAS No.:592532-29-1
Molecular Formula:C₄₆H₄₆ClN₃O₇
Molecular Weight:788.34
Hs Code.:

Benzoic acid,
2-[[4-[2-(acetylamino)-3-[[(4-chlorophenyl)methyl]amino]-3-oxopropyl]-2-
ethylphenyl][(1,1-dimethylethoxy)oxoacetyl]amino]-, diphenylmethyl ester

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Chemical Property of Benzoic acid, 2-[[4-[2-(acetylamino)-3-[[(4-chlorophenyl)methyl]amino]-3-oxopropyl]-2- ethylphenyl][(1,1-dimethylethoxy)oxoacetyl]amino]-, diphenylmethyl ester

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Technology Process of Benzoic acid, 2-[[4-[2-(acetylamino)-3-[[(4-chlorophenyl)methyl]amino]-3-oxopropyl]-2- ethylphenyl][(1,1-dimethylethoxy)oxoacetyl]amino]-, diphenylmethyl ester

There total 6 articles about Benzoic acid, 2-[[4-[2-(acetylamino)-3-[[(4-chlorophenyl)methyl]amino]-3-oxopropyl]-2- ethylphenyl][(1,1-dimethylethoxy)oxoacetyl]amino]-, diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 436864-41-4
benzyl (2E)-2-(acetylamino)-3-(4-amino-3-ethylphenyl)-2-propenoate

: 592532-29-1
2-({4-[2-acetylamino-2-(4-chloro-benzylcarbamoyl)-ethyl]-2-ethyl-phenyl}-tert-butoxyoxalyl-amino)-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂ / 10 percent Pd/C / 20 °C / 3040 Torr

2: 62 percent / Cs₂CO₃ / 20 °C

3: 85 percent / Cu(OAc)2 / propan-2-ol / 80 °C

4: 72 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

5: 92 percent / acetone / 20 °C

6: 100 percent / morpholine; Pd(PPh₃)4 / CH₂Cl₂

7: TBTU; i-Pr₂NEt / dimethylformamide

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1016/S0960-894X(03)00302-0

Reference yield:

: 402924-97-4
2-acetylamino-3-(4-amino-3-ethyl-phenyl)-propionic acid

: 592532-29-1
2-({4-[2-acetylamino-2-(4-chloro-benzylcarbamoyl)-ethyl]-2-ethyl-phenyl}-tert-butoxyoxalyl-amino)-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / Cs₂CO₃ / 20 °C

2: 85 percent / Cu(OAc)2 / propan-2-ol / 80 °C

3: 72 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

4: 92 percent / acetone / 20 °C

5: 100 percent / morpholine; Pd(PPh₃)4 / CH₂Cl₂

6: TBTU; i-Pr₂NEt / dimethylformamide

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1016/S0960-894X(03)00302-0

Reference yield:

: 592531-95-8
2-[4-(2-acetylamino-2-allyloxycarbonylethyl)-2-ethylphenylamino]-benzoic acid

: 592532-29-1
2-({4-[2-acetylamino-2-(4-chloro-benzylcarbamoyl)-ethyl]-2-ethyl-phenyl}-tert-butoxyoxalyl-amino)-benzoic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

2: 92 percent / acetone / 20 °C

3: 100 percent / morpholine; Pd(PPh₃)4 / CH₂Cl₂

4: TBTU; i-Pr₂NEt / dimethylformamide

With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(03)00302-0