1-METHYL-2-BENZIMIDAZOLINONE

Base Information

• Chemical Name: 1-METHYL-2-BENZIMIDAZOLINONE
• CAS No.: 1849-01-0
• Molecular Formula: C8H8 N2 O
• Molecular Weight: 148.164
• Hs Code.: 29339980
• Mol file: 1849-01-0.mol

Synonyms:2-Benzimidazolinone,1-methyl- (6CI,7CI,8CI); 1-Methyl-1,3-dihydro-2H-benzimidazol-2-one;1-Methyl-1,3-dihydrobenzimidazol-2-one; 1-Methyl-1H-benzo[d]imidazol-2(3H)-one;1-Methyl-2-benzimidazolinone; 1-Methyl-2-benzimidazolone;1-Methylbenzimidazol-2(3H)-one; 1-Methylbenzimidazol-2-ol;3-Methyl-2-benzimidazolone; N-Methyl-2-benzimidazolinone

Chemical Property of 1-METHYL-2-BENZIMIDAZOLINONE

Chemical Property:

• Melting Point: 192-196 °C
• Refractive Index: 1.6000 (estimate)
• Boiling Point: °Cat760mmHg
• PKA: 12.29±0.30(Predicted)
• Flash Point: °C
• PSA: 37.79000
• Density: 1.213g/cm³
• LogP: 0.86660
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-2-benzimidazolinone ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYL-2-BENZIMIDAZOLINONE

There total 68 articles about 1-METHYL-2-BENZIMIDAZOLINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-Methyl-3-(1-phenyl-vinyl)-1,3-dihydro-benzoimidazol-2-one (77556-91-3) → 1-methyl-2-benzimidazolone (1849-01-0)

Guidance literature:

With hydrogenchloride; In water; at 60 ℃; for 1h;

Reference yield: 91.0%

(1H-benzo[d][1,2,3]triazol-1-yl)[2-(methylamino)phenyl]methanone → 1-methyl-2-benzimidazolone (1849-01-0)

Guidance literature:

With trimethylsilylazide; triethylamine; aniline; In toluene; at 110 ℃; for 1h; Sealed tube;

DOI:10.1055/s-0039-1689937

Reference yield: 86.0%

carbon dioxide (124-38-9,18923-20-1) + N-methyl-1,2-phenylenediamine (4760-34-3) → 1-methyl-2-benzimidazolone (1849-01-0)

Guidance literature:

With 2,3,4,5,7,8,9,10-octahydropyrimido[1,2-a]azepin-1-ium acetate; In neat (no solvent); at 120 ℃; for 24h; under 67506.8 Torr;

DOI:10.1021/cs400256j

upstream raw materials:

1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole

2-(benzylsulfonyl)-1-methyl-1H-benzo[d]imidazole

(2-methylamino-phenyl)-urea

phosgene

Downstream raw materials:

1-methyl-3-[(1R)-3-(chloro)-1-phenylpropyl]-1,3-dihydro-2H-benzimidazol-2-one

1-methyl-3-phenyl-1,3-dihydro-2H-benzo[d]imidazol-2-one

1-((2-(1-ethoxyethoxy)phenyl)ethynyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one

2-chloro-1-methyl-benzimidazole

Refernces

• 1、 Khalikov, S. S.,Molchanov, L. V.,Kadyrov, Ch. Sh.. "OXIDATION OF BENZIMIDAZOLES TO BENZIMIDAZOLONES". . p. 124 - 125. Retrieved 1983.
• 2、 Avery, Bonnie A.,Chin, Frederick T.,Intagliata, Sebastiano,King, Tamara I.,Matsumoto, Rae R.,McCurdy, Christopher R.,McLaughlin, Jay P.,Mesangeau, Christophe,Seminerio, Michael,Sharma, Abhisheak,Wilson, Lisa L.. "Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo". . . Retrieved 2020.
• 3、 Hongsibsong, Surat,Pattarawarapan, Mookda,Phakhodee, Wong,Wiriya, Nittaya,Yamano, Dolnapa. "Direct Synthesis of N-Monosubstituted Benzimidazol-2-ones via Ph 3P-I 2-Mediated Reaction of Hydroxamic Acids". supporting information. . Retrieved 2022/03/01.
• 4、 Jarrige, Lucie,Zhou, Zijun,Hemming, Marcel,Meggers, Eric. "Efficient Amination of Activated and Non-Activated C(sp3)?H Bonds with a Simple Iron–Phenanthroline Catalyst". supporting information. p. 6314 - 6319. Retrieved 2021/02/01.