1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole

Base Information

• Chemical Name: 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole
• CAS No.: 61078-14-6
• Molecular Formula: C9H10N2O2S
• Molecular Weight: 210.257
• Mol file: 61078-14-6.mol

Synonyms:1H-benzimidazole,1-methyl-2-(methylsulfonyl);2-Methansulfonyl-1-methyl-1H-benzimidazol;2-Methylsulfonyl-1-methylbenzimidazol;HMS1378J16;1-methyl-2-methylsulfonyl-benzimidazole;2-methylsulfonyl-1-methyl-1H-benzimidazole;2-methanesulfonyl-1-methyl-1H-benzoimidazole;2-methanesulfonyl-1-methyl-1H-benzimidazole;

Chemical Property of 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole

Chemical Property:

• Melting Point: 132.0 to 136.0 °C
• PSA: 60.34000
• LogP: 2.05760

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-2-(methylsulfonyl)benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole

There total 9 articles about 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-methyl-2-(methylthio)-1H-benzimidazole (4344-61-0) → 1-methyl-1,3-dihydro-2H-benzimidazole-2-thione (2360-22-7) + 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole (61078-14-6)

Guidance literature:

With oxone; In methanol; water; at 20 ℃; for 5h; Reagent/catalyst; Solvent; Time;

DOI:10.1021/acs.orglett.5b01049

Reference yield: 80.0%

2-(methylsulfonyl)-1H-benzo[d]imidazole (57159-81-6) + methyl iodide (74-88-4) → 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole (61078-14-6)

Guidance literature:

2-(methylsulfonyl)-1H-benzo[d]imidazole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; for 18h;

DOI:10.1002/chem.202102124

Reference yield:

2-(methylsulfonyl)-1H-benzo[d]imidazole (57159-81-6) + water (7732-18-5) + methyl iodide (74-88-4) → 1-methyl-2-(methylsulfonyl)-1H-benzo[d]imidazole (61078-14-6)

Guidance literature:

With NaH; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

2-(methylsulfonyl)-1H-benzo[d]imidazole

methylene chloride

2-methylsulfanylbenzimidazole

water

Downstream raw materials:

1-methyl-2-benzimidazolone

N-benzyl-1-methyl-1H-benzo[d]imidazol-2-amine

4-bromo-α-methylstyrene

2-methylideneadamantane