Benzoic acid, 2-[8-[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-5-phenylpentyl ]-8-azabicyclo[3.2.1]oct-3-yl]-, ethyl ester

Base Information

• Chemical Name: Benzoic acid, 2-[8-[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-5-phenylpentyl ]-8-azabicyclo[3.2.1]oct-3-yl]-, ethyl ester
• CAS No.: 593266-77-4
• Molecular Formula: C32H42N2O5
• Molecular Weight: 534.696
• Mol file: 593266-77-4.mol

Synonyms:

Chemical Property of Benzoic acid, 2-[8-[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-5-phenylpentyl ]-8-azabicyclo[3.2.1]oct-3-yl]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 2-[8-[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-5-phenylpentyl ]-8-azabicyclo[3.2.1]oct-3-yl]-, ethyl ester

There total 5 articles about Benzoic acid, 2-[8-[(2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxo-5-phenylpentyl ]-8-azabicyclo[3.2.1]oct-3-yl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromobenzoic acid ethyl ester (6091-64-1) → 2-[8-(2-tert-butoxycarbonylamino-5-phenyl-pentanoyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-benzoic acid ethyl ester (593266-77-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 42 percent / (Ph₃P)4Pd / toluene / Heating

2: 97 percent / H₂ / 10 percent Pd/C / methanol / 20 h / 760 Torr

3: 100 percent / HCl / dioxane

4: EDC; HOBT; 4-methylmorpholine / 20 °C

With 4-methyl-morpholine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; toluene; 1: Stille coupling;

DOI:10.1016/S0960-894X(03)00261-0

Reference yield:

tert-butyl 3-(trimethylstannyl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate → 2-[8-(2-tert-butoxycarbonylamino-5-phenyl-pentanoyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-benzoic acid ethyl ester (593266-77-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 42 percent / (Ph₃P)4Pd / toluene / Heating

2: 97 percent / H₂ / 10 percent Pd/C / methanol / 20 h / 760 Torr

3: 100 percent / HCl / dioxane

4: EDC; HOBT; 4-methylmorpholine / 20 °C

With 4-methyl-morpholine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol; toluene; 1: Stille coupling;

DOI:10.1016/S0960-894X(03)00261-0

Reference yield:

3-(2-ethoxycarbonyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester (185099-70-1) → 2-[8-(2-tert-butoxycarbonylamino-5-phenyl-pentanoyl)-8-aza-bicyclo[3.2.1]oct-3-yl]-benzoic acid ethyl ester (593266-77-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / H₂ / 10 percent Pd/C / methanol / 20 h / 760 Torr

2: 100 percent / HCl / dioxane

3: EDC; HOBT; 4-methylmorpholine / 20 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In 1,4-dioxane; methanol;

DOI:10.1016/S0960-894X(03)00261-0

upstream raw materials:

2-(tert-butoxycarbonylamino)-5-phenyl-D-pentanoic acid

2-bromobenzoic acid ethyl ester

3-(2-ethoxycarbonyl-phenyl)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester

3-(2-ethoxycarbonyl-phenyl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester

Downstream raw materials:

2-{8-[2-(2-tert-butoxycarbonylamino-2-methyl-propionylamino)-5-phenyl-pentanoyl]-8-aza-bicyclo[3.2.1]oct-3-yl}-benzoic acid ethyl ester