Carbamic acid, [1,1-dimethyl-2-[[(1R)-1-[[3-(2-methylphenyl)-8-azabicyclo[3.2.1]oct-8-yl] carbonyl]-4-phenylbutyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [1,1-dimethyl-2-[[(1R)-1-[[3-(2-methylphenyl)-8-azabicyclo[3.2.1]oct-8-yl] carbonyl]-4-phenylbutyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester
CAS No.:593266-79-6
Molecular Formula:C₃₄H₄₇N₃O₄
Molecular Weight:561.765
Hs Code.:

Carbamic acid,
[1,1-dimethyl-2-[[(1R)-1-[[3-(2-methylphenyl)-8-azabicyclo[3.2.1]oct-8-yl]
carbonyl]-4-phenylbutyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, [1,1-dimethyl-2-[[(1R)-1-[[3-(2-methylphenyl)-8-azabicyclo[3.2.1]oct-8-yl] carbonyl]-4-phenylbutyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [1,1-dimethyl-2-[[(1R)-1-[[3-(2-methylphenyl)-8-azabicyclo[3.2.1]oct-8-yl] carbonyl]-4-phenylbutyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester

There total 5 articles about Carbamic acid, [1,1-dimethyl-2-[[(1R)-1-[[3-(2-methylphenyl)-8-azabicyclo[3.2.1]oct-8-yl] carbonyl]-4-phenylbutyl]amino]-2-oxoethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30992-29-1
Boc-Aib-OH

: 2-amino-5-phenyl-1-(3-o-tolyl-8-aza-bicyclo[3.2.1]oct-8-yl)-pentan-1-one

: 593266-79-6
{1-methyl-1-[4-phenyl-1-(3-o-tolyl-8-aza-bicyclo[3.2.1]octane-8-carbonyl)-butylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1016/S0960-894X(03)00261-0

Reference yield:

: 532-24-1
tropinone

: 593266-79-6
{1-methyl-1-[4-phenyl-1-(3-o-tolyl-8-aza-bicyclo[3.2.1]octane-8-carbonyl)-butylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: KN(TMS)2 / tetrahydrofuran / -78 °C

1.2: 75 percent / tetrahydrofuran / -78 °C

2.1: 94 percent / CuI / tetrahydrofuran / 0 °C

3.1: 82 percent / NH₃; Na / tetrahydrofuran / -78 °C

4.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / Heating

4.2: methanol / Heating

5.1: EDC; HOBT; 4-methylmorpholine / 20 °C

6.1: 100 percent / HCl / ethyl acetate / 20 °C

7.1: EDC; HOBT; 4-methylmorpholine / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; hydrogenchloride; copper(l) iodide; carbonochloridic acid 1-chloro-ethyl ester; ammonia; sodium; potassium hexamethylsilazane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00261-0

Reference yield:

: 185099-66-5
8-methyl-3-o-tolyl-8-aza-bicyclo[3.2.1]octane

: 593266-79-6
{1-methyl-1-[4-phenyl-1-(3-o-tolyl-8-aza-bicyclo[3.2.1]octane-8-carbonyl)-butylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: α-chloroethyl chloroformate / 1,2-dichloro-ethane / Heating

1.2: methanol / Heating

2.1: EDC; HOBT; 4-methylmorpholine / 20 °C

3.1: 100 percent / HCl / ethyl acetate / 20 °C

4.1: EDC; HOBT; 4-methylmorpholine / CH₂Cl₂ / 20 °C

With 4-methyl-morpholine; hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/S0960-894X(03)00261-0