1H-Indole-2-carboxylic acid, 5-bromo-3-phenyl-, ethyl ester

Base Information

• Chemical Name: 1H-Indole-2-carboxylic acid, 5-bromo-3-phenyl-, ethyl ester
• CAS No.: 59394-42-2
• Molecular Formula: C17H14BrNO2
• Molecular Weight: 344.208
• Mol file: 59394-42-2.mol

Synonyms:5-Brom-3-phenyl-indol-2-carbonsaeure-aethylester;ethyl 5-bromo-3-phenylindole-2-carboxylate;Ethyl 5-bromo-3-phenyl-1H-indole-2-carboxylate;5-bromo-3-phenyl-indole-2-carboxylic acid ethyl ester;

Chemical Property of 1H-Indole-2-carboxylic acid, 5-bromo-3-phenyl-, ethyl ester

Chemical Property:

• PSA: 42.09000
• LogP: 4.77410

Purity/Quality:

99% ^*data from raw suppliers

Ethyl 5-bromo-3-phenyl-1H-indole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indole-2-carboxylic acid, 5-bromo-3-phenyl-, ethyl ester

There total 8 articles about 1H-Indole-2-carboxylic acid, 5-bromo-3-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(E)-ethyl 2-(2-(4-bromophenyl)hydrazono)-3-phenylpropanoate → ethyl 5-bromo-3-phenyl-1H-indole-2-carboxylate (59394-42-2)

Guidance literature:

With thionyl chloride; In ethanol; at 80 ℃;

DOI:10.1016/j.tetlet.2005.11.126

Reference yield:

C17H17BrN2O2 → ethyl 5-bromo-3-phenyl-1H-indole-2-carboxylate (59394-42-2)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 4h;

DOI:10.1016/j.bioorg.2021.104795

Reference yield:

Ethyl 2-benzylacetoacetate (620-79-1) + 4-bromo-aniline (106-40-1) → ethyl 5-bromo-3-phenyl-1H-indole-2-carboxylate (59394-42-2)

Guidance literature:

4-bromo-aniline; With hydrogenchloride; sodium nitrite; In water;

Ethyl 2-benzylacetoacetate; With potassium hydroxide; In ethanol; water; at 0 ℃; for 0.5h;

With hydrogenchloride; In ethanol; for 2h; Further stages.;

DOI:10.1080/00397910801914160

upstream raw materials:

(4-bromophenyl)diazonium chloride

Ethyl 2-benzylacetoacetate

2-diazo-3-phenyl-propionic acid ethyl ester

4-bromo-aniline

Downstream raw materials:

C₁₆H₁₁BrN₄S

C₂₂H₂₀N₂O₃

1-(2-Amino-ethyl)-5-bromo-3-phenyl-1H-indole-2-carboxylic acid ethyl ester

8-Bromo-10-phenyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole