Ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate

Base Information

Chemical Name:Ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate
CAS No.:74991-95-0
Molecular Formula:C₁₃H₂₃NO₄
Molecular Weight:257.33
Hs Code.:
NSC Number:135437
DSSTox Substance ID:DTXSID90300228

Synonyms:ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate;74991-95-0;Ethyl 3-(2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl)propanoate;NSC135437;DTXSID90300228;AKOS024321385;NSC-135437;ETHYL 3-[2-(2-ETHOXY-2-OXOETHYL)-1-PYRROLIDINYL]PROPANOATE

Suppliers and Price of Ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate

Chemical Property:

Vapor Pressure:0.00012mmHg at 25°C
Boiling Point:335.4°Cat760mmHg
Flash Point:156.6°C
Density:1.052g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:257.16270821
Heavy Atom Count:18
Complexity:280

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CCN1CCCC1CC(=O)OCC

Technology Process of Ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate

There total 3 articles about Ethyl 3-[2-(2-ethoxy-2-oxoethyl)pyrrolidin-1-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 74991-94-9
3-{2-[1-Ethoxycarbonyl-meth-(E)-ylidene]-pyrrolidin-1-yl}-propionic acid ethyl ester

: 74991-95-0
3-(2-Ethoxycarbonylmethyl-pyrrolidin-1-yl)-propionic acid ethyl ester

Guidance literature:: With hydrogen; platinum(IV) oxide; In acetic acid;
DOI:10.1016/S0040-4039(00)74580-1

Reference yield:

: 74991-93-8
ethyl 3-(2-thioxopyrrolidin-1-yl)propanoate

: 74991-95-0
3-(2-Ethoxycarbonylmethyl-pyrrolidin-1-yl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) Ph₃P, Et₃N / 1.) CH₃CN, room temperature, 16h; 2.) CH₃CN,room temperature;

2: 90 percent / H₂ / PtO₂ / acetic acid

With hydrogen; triethylamine; triphenylphosphine; platinum(IV) oxide; In acetic acid;
DOI:10.1016/S0040-4039(00)74580-1

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 74991-95-0
3-(2-Ethoxycarbonylmethyl-pyrrolidin-1-yl)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / NaOH / tetrahydrofuran / 3.5 h / 55 °C

2: 2.) Ph₃P, Et₃N / 1.) CH₃CN, room temperature, 16h; 2.) CH₃CN,room temperature;

3: 90 percent / H₂ / PtO₂ / acetic acid

With hydrogen; triethylamine; triphenylphosphine; platinum(IV) oxide; sodium hydroxide; In tetrahydrofuran; acetic acid;
DOI:10.1016/S0040-4039(00)74580-1