Hexanoic acid, 3-[2-[[2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-2-(methoxymethylene)-4- [[(phenylmethoxy)carbonyl]oxy]-, methyl ester, (2E,3R,4R)-

Base Information

Chemical Name:Hexanoic acid, 3-[2-[[2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-2-(methoxymethylene)-4- [[(phenylmethoxy)carbonyl]oxy]-, methyl ester, (2E,3R,4R)-
CAS No.:595583-85-0
Molecular Formula:C29H34N2O7
Molecular Weight:522.598
Hs Code.:

Hexanoic acid,
3-[2-[[2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-2-(methoxymethylene)-4-
[[(phenylmethoxy)carbonyl]oxy]-, methyl ester, (2E,3R,4R)-

Synonyms:

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Chemical Property of Hexanoic acid, 3-[2-[[2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-2-(methoxymethylene)-4- [[(phenylmethoxy)carbonyl]oxy]-, methyl ester, (2E,3R,4R)-

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Technology Process of Hexanoic acid, 3-[2-[[2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-2-(methoxymethylene)-4- [[(phenylmethoxy)carbonyl]oxy]-, methyl ester, (2E,3R,4R)-

There total 6 articles about Hexanoic acid, 3-[2-[[2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-2-(methoxymethylene)-4- [[(phenylmethoxy)carbonyl]oxy]-, methyl ester, (2E,3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 31139-36-3
dibenzyl dicarbonate

: 595583-83-8
(3R,4R)-4-Hydroxy-3-{[2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-2-[1-methoxy-meth-(E)-ylidene]-hexanoic acid methyl ester

: 595583-85-0
(3R,4R)-4-Benzyloxycarbonyloxy-3-{[2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-2-[1-methoxy-meth-(E)-ylidene]-hexanoic acid methyl ester

Guidance literature:: With CeCl₂; In tetrahydrofuran; at 60 ℃; for 1h;
DOI:10.1021/ol035128a

Reference yield:

: 76291-90-2
(-)-(R)-5-ethyl-2(5H)-furanone

: 595583-85-0
(3R,4R)-4-Benzyloxycarbonyloxy-3-{[2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-2-[1-methoxy-meth-(E)-ylidene]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: t-BuOK / 2-methyl-propan-2-ol / 0.17 h / 20 °C

1.2: 88 percent / 2-methyl-propan-2-ol / 3 h / 20 °C

2.1: 100 percent / Et₃SiH / Pd/C / acetone / 3 h / 20 °C

3.1: 88 percent / ethanol / 0 °C

4.1: 85 percent / Me₃Al / hexane; CH₂Cl₂ / 5.5 h / 20 °C

5.1: 85 percent / CeCl₂ / tetrahydrofuran / 1 h / 60 °C

With triethylsilane; potassium tert-butylate; trimethylaluminum; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1021/ol035128a

Reference yield:

: 595583-78-1
(Z)-(R)-4-(Tetrahydro-pyran-2-yloxy)-hex-2-enoic acid methyl ester

: 595583-85-0
(3R,4R)-4-Benzyloxycarbonyloxy-3-{[2-(1H-indol-3-yl)-ethylcarbamoyl]-methyl}-2-[1-methoxy-meth-(E)-ylidene]-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: p-TsOH*H₂O / methanol / 1.5 h / 20 °C

2.1: t-BuOK / 2-methyl-propan-2-ol / 0.17 h / 20 °C

2.2: 88 percent / 2-methyl-propan-2-ol / 3 h / 20 °C

3.1: 100 percent / Et₃SiH / Pd/C / acetone / 3 h / 20 °C

4.1: 88 percent / ethanol / 0 °C

5.1: 85 percent / Me₃Al / hexane; CH₂Cl₂ / 5.5 h / 20 °C

6.1: 85 percent / CeCl₂ / tetrahydrofuran / 1 h / 60 °C

With triethylsilane; potassium tert-butylate; trimethylaluminum; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetone; tert-butyl alcohol;
DOI:10.1021/ol035128a