((6,7-Dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid

Base Information

Chemical Name:((6,7-Dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid
CAS No.:66015-25-6
Molecular Formula:C₁₈H₁₃Cl₂FO₄
Molecular Weight:383.203
Hs Code.:
DSSTox Substance ID:DTXSID30984480
ChEMBL ID:CHEMBL3249642
Mol file:66015-25-6.mol

Synonyms:((6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid;DFMOIAA

Suppliers and Price of ((6,7-Dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of ((6,7-Dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid

Chemical Property:

Vapor Pressure:7.21E-13mmHg at 25°C
Boiling Point:548.6°Cat760mmHg
Flash Point:285.6°C
PSA：63.60000
Density:1.468g/cm³
LogP:4.29260
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:382.0174924
Heavy Atom Count:25
Complexity:537

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O)C3=CC=C(C=C3)F

Technology Process of ((6,7-Dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid

There total 8 articles about ((6,7-Dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl)oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66015-50-7
6,7-dichloro-2-p-fluorophenyl-2,3-dihydro-5-hydroxy-2-methyl-1H-inden-1-one

: 105-36-2
ethyl bromoacetate

: 66015-25-6,89269-92-1,89269-93-2
(+/-)-<<6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl>oxy>acetic acid

Guidance literature:: With hydrogenchloride; sodium hydroxide; potassium carbonate; In N-methyl-acetamide; water;

Reference yield:

: 1984-59-4
2,3-dichloroanisole

: 66015-25-6,89269-92-1,89269-93-2
(+/-)-<<6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl>oxy>acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: aluminium trichloride / dichloromethane

2: bromine; sodium hydrogensulfite / acetic acid

3: lithium bromide / N,N-dimethyl-formamide

4: (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid

5: potassium tert-butylate / water; tert-butyl alcohol

6: pyridine hydrochloride

7: hydrogenchloride; sodium hydroxide; potassium carbonate / N-methyl-acetamide; water

With hydrogenchloride; sodium hydroxide; lithium bromide; potassium tert-butylate; bromine; pyridine hydrochloride; potassium carbonate; sodium hydrogensulfite; aluminium trichloride; In N-methyl-acetamide; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; sulfuric acid; water; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 54196-91-7
6,7-dichloro-5-methoxy-2-methyl-1-indanone

: 66015-25-6,89269-92-1,89269-93-2
(+/-)-<<6,7-dichloro-2-(4-fluorophenyl)-2-methyl-1-oxo-5-indanyl>oxy>acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / water; tert-butyl alcohol

2: pyridine hydrochloride

3: hydrogenchloride; sodium hydroxide; potassium carbonate / N-methyl-acetamide; water

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; pyridine hydrochloride; potassium carbonate; In N-methyl-acetamide; water; tert-butyl alcohol;