[1-(6-Chloro-pyriMidin-4-yl)-piperidin-4-yl]-carbaMic acid tert-butyl ester, 98+% C14H21ClN4O2, MW: 312.8

Base Information

• Chemical Name: [1-(6-Chloro-pyriMidin-4-yl)-piperidin-4-yl]-carbaMic acid tert-butyl ester, 98+% C14H21ClN4O2, MW: 312.8
• CAS No.: 596817-50-4
• Molecular Formula: C14H21ClN4O2
• Molecular Weight: 312.79500
• Hs Code.: 2933990090
• Mol file: 596817-50-4.mol

Synonyms:tert-Butyl (1-(6-chloropyrimidin-4-yl)piperidin-4-yl)carbamate;[1-(6-Chloro-pyrimidin-4-yl)piperidin-4-yl]-carbamic acid tert-butyl ester;(tert-butoxy)-N-[1-(6-chloropyrimidin-4-yl)(4-piperidyl)]carboxamide;

Chemical Property of [1-(6-Chloro-pyriMidin-4-yl)-piperidin-4-yl]-carbaMic acid tert-butyl ester, 98+% C14H21ClN4O2, MW: 312.8

Chemical Property:

• Boiling Point: 476.7±45.0 °C(Predicted)
• PKA: 12.08±0.20(Predicted)
• PSA: 70.84000
• Density: 1.24
• LogP: 2.89290

Purity/Quality:

tert-Butyl(1-(6-chloropyrimidin-4-yl)piperidin-4-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1-(6-Chloro-pyriMidin-4-yl)-piperidin-4-yl]-carbaMic acid tert-butyl ester, 98+% C14H21ClN4O2, MW: 312.8

There total 2 articles about [1-(6-Chloro-pyriMidin-4-yl)-piperidin-4-yl]-carbaMic acid tert-butyl ester, 98+% C14H21ClN4O2, MW: 312.8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,6-dichloropyrimidine (1193-21-1) + (piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → tert-butyl 1-(6-chloropyrimidin-4-yl)piperidin-4-ylcarbamate (596817-50-4)

Guidance literature:

With triethylamine; In acetonitrile; at 120 ℃; for 2h; microwave irradiation;

Reference yield:

→ tert-butyl 1-(6-chloropyrimidin-4-yl)piperidin-4-ylcarbamate (596817-50-4)

Guidance literature:

Reference yield:

tert-butyl 1-(6-chloropyrimidin-4-yl)piperidin-4-ylcarbamate (596817-50-4) → 1-(4-methyl benzoate)-3-(1-(6-(4-phenoxyphenyl)pyrimidin-4-yl)piperidin-4-yl)urea

Guidance literature:

Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: dichloromethane / 0.17 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / 0.17 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; dichloromethane; 1: |Suzuki Coupling;

DOI:10.1007/s00044-016-1668-x

upstream raw materials:

4,6-dichloropyrimidine

(piperidin-4-yl)carbamic acid tert-butyl ester