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Product FOB Price Min.Order Supply Ability Supplier
High Purity Raw Material 4-(N-BOC-AMINO)PIPERIDINE
Cas No: 73874-95-0
USD $ 150.0-200.0 / Kilogram 1 Kilogram 50000 Metric Ton/Month Shanlong Biotechnology (hebei) Co., Ltd. Contact Supplier
4-N-Boc-aminopiperidine CAS#73874-95-0
Cas No: 73874-95-0
No Data 1 Kilogram 50 Metric Ton/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier
4-N-(tert-Butoxycarbonyl)aminopiperidine
Cas No: 73874-95-0
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
4-Boc-aminopiperidine
Cas No: 73874-95-0
USD $ 600.0-800.0 / Kilogram 1 Kilogram 5 Metric Ton/Month Anhui Dexinjia Biopharm Co., Ltd Contact Supplier
4-(tert-Butoxycarbonylamino)-piperidine
Cas No: 73874-95-0
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
4-N-BOC-Aminopiperidine
Cas No: 73874-95-0
No Data No Data No Data Shanghai Sunwise Chemical Co., Ltd Contact Supplier
4-N-BOC-Aminopiperidine Manufacturer/High quality/Best price/In stock
Cas No: 73874-95-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
bestfactory 4-N-BOC-Aminopiperidine
Cas No: 73874-95-0
No Data 1 Kilogram 100 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
4-N-BOC-Aminopiperidine
Cas No: 73874-95-0
USD $ 8.0-8.0 / Gram 1 Gram 100 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Manufacturer supply CAS 73874-95-0 with best quality
Cas No: 73874-95-0
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier

73874-95-0 Usage

Chemical Properties

off-white crystalline powder

Description

4-(N-Boc-amino)piperidone may be used as a functionalization reagent for introduction of a primary and a tertiary amino group to poly(2-isopropyl-2-oxazoline. It can also be used as pharma building block. It is used in the synthesis of a piperidine-4-carboxamide CCR5 antagonist with potent anti-HIV 1-activity. It is an intermediate for the synthesis of various pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents. It is used for the synthesis of diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 Antagonists.
InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-8-4-6-11-7-5-8/h8,11H,4-7H2,1-3H3,(H,12,13)/p+1

73874-95-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (540935)  4-(N-Boc-amino)piperidine  96% 73874-95-0 540935-25G 3,607.11CNY Detail
Aldrich (540935)  4-(N-Boc-amino)piperidine  96% 73874-95-0 540935-5G 1,056.51CNY Detail
Aldrich (540935)  4-(N-Boc-amino)piperidine  96% 73874-95-0 540935-1G 339.30CNY Detail
Alfa Aesar (H28517)  4-(Boc-amino)piperidine, 96%    73874-95-0 25g 5943.0CNY Detail
Alfa Aesar (H28517)  4-(Boc-amino)piperidine, 96%    73874-95-0 5g 1982.0CNY Detail
Alfa Aesar (H28517)  4-(Boc-amino)piperidine, 96%    73874-95-0 1g 594.0CNY Detail

73874-95-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Boc-aminopiperidine

1.2 Other means of identification

Product number -
Other names tert-butyl N-piperidin-4-ylcarbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:73874-95-0 SDS

73874-95-0Synthetic route

tert-butyl (1-benzylpiperidin-4-yl)carbamate
73889-19-7

tert-butyl (1-benzylpiperidin-4-yl)carbamate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol for 12h;99%
With hydrogen; palladium 10% on activated carbon In methanol for 12h;99%
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 18h;97%
C17H24N2O2

C17H24N2O2

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 70℃; under 6000.6 - 7500.75 Torr; for 4h; Reagent/catalyst; Temperature;90.7%
1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopiperidine
159874-20-1

1-benzyloxycarbonyl-4-tert-butoxycarbonylaminopiperidine

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2068.59 Torr;
palladium In ethanol1.8 g (100%)
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

4-formylimidazole on 2-Cl-Trityl cross-linked PS-resin

4-formylimidazole on 2-Cl-Trityl cross-linked PS-resin

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / NaOH / 2-methyl-propan-2-ol / 20 °C
2: 95 percent / H2 / Pd/C / methanol / 20 °C
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

1.) NaH; 2.) SOCl2

1.) NaH; 2.) SOCl2

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / NaOH / 2-methyl-propan-2-ol / 20 °C
2: 95 percent / H2 / Pd/C / methanol / 20 °C
View Scheme
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / acetonitrile / 1 h / 20 °C
2: 92 percent / cyclohexene / 20 percent Pd(OH)2/C / ethanol / 3.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 99 percent / CH2Cl2 / 18 h / Ambient temperature
2: 97 percent / H2 / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / acetonitrile / 1 h / 20 °C
2: 92 percent / cyclohexene / 20 percent Pd(OH)2/C / ethanol / 3.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / dichloromethane / 4 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol
View Scheme
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / water; 1,4-dioxane / 25 h / 5 - 20 °C
2: palladium 10% on activated carbon; ammonium formate / methanol / 2 h / 65 °C / Reflux
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 12 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 24 h
View Scheme
benzyl 4-isocyanatotetrahydro-1(2H)-pyridinecarboxylate
220394-91-2

benzyl 4-isocyanatotetrahydro-1(2H)-pyridinecarboxylate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CuCl2 / 20 °C
2: H2 / 10 percent Pd/C / methanol / 2068.59 Torr
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium

pentacarbonyl<1-<<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl>oxy>-(E)-3-phenyl-2-propenylidene>chromium

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 99 percent / CH2Cl2 / 18 h / Ambient temperature
2: 97 percent / H2 / 10 percent Pd/C / methanol / 18 h / 2585.74 Torr
View Scheme
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine; palladium dihydroxide; hydrogen In dichloromethane; water
Stage #1: 4-amino-1-benzylpiperidine; di-tert-butyl dicarbonate With triethylamine
Stage #2: With palladium on activated charcoal; hydrogen
Multi-step reaction with 2 steps
1: triethylamine / tetrahydrofuran / 12 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 24 h
View Scheme
Multi-step reaction with 2 steps
1: chloroform
2: acetic acid / palladium-carbon catalyst / methanol
View Scheme
4-amino-1-benzylpiperidine
50541-93-0

4-amino-1-benzylpiperidine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl (1-benzylpiperidin-4-yl)carbamate
73889-19-7

tert-butyl (1-benzylpiperidin-4-yl)carbamate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
In tetrahydrofuran; palladium-carbon; ethanol; n-heptane
3,5-dichlorobenzyl alcohol
60211-57-6

3,5-dichlorobenzyl alcohol

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate; 1,1'-carbonyldiimidazole In ethyl acetate; N,N-dimethyl-formamide
C13H18N2O

C13H18N2O

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 5 °C / Reflux; Inert atmosphere
2: triethylamine / dichloromethane / 20 °C
3: formic acid; potassium hydroxide; / ethanol / 1 h / 70 °C
View Scheme
1-phenylmethyl-4-piperidone
3612-20-2

1-phenylmethyl-4-piperidone

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium carbonate; hydroxylamine hydrochloride / methanol / 4 h / Reflux
2: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 5 °C / Reflux; Inert atmosphere
3: triethylamine / dichloromethane / 20 °C
4: formic acid; potassium hydroxide; / ethanol / 1 h / 70 °C
View Scheme
2-(4-chloro-7-methylquinazolin-2-yl)-phenol
757982-39-1

2-(4-chloro-7-methylquinazolin-2-yl)-phenol

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl 1-(2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-4-yl-carbamate

tert-butyl 1-(2-(2-hydroxyphenyl)-7-methylquinazolin-4-yl)piperidin-4-yl-carbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane for 6h;100%
With triethylamine In dichloromethane at 20℃;69%
benzoyl chloride
98-88-4

benzoyl chloride

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl N-(1-benzoylpiperidin-4-yl)carbamate
429677-00-9

tert-butyl N-(1-benzoylpiperidin-4-yl)carbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; Ice cooling;100%
With triethylamine In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;96%
With triethylamine In dichloromethane for 18h;91%
With triethylamine In dichloromethane at 20℃; for 2h;
With triethylamine In dichloromethane at 20℃; for 2h;
4-chlorothieno[3,2-d]pyrimidine
16269-66-2

4-chlorothieno[3,2-d]pyrimidine

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

(1-thieno[2,3-d]pyrimidin-4-yl-piperidin-4-yl)-carbamic acid tert-butyl ester

(1-thieno[2,3-d]pyrimidin-4-yl-piperidin-4-yl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With triethylamine In butan-1-ol at 100℃; for 48h;100%
cyclopentyl iodide
1556-18-9

cyclopentyl iodide

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

4-(N-(tert-butyloxycarbonyl)amino)piperidine
936221-73-7

4-(N-(tert-butyloxycarbonyl)amino)piperidine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 48h;100%
(7-fluoro-2-oxo-1(2H)-quinolinyl)acetaldehyde
1003944-27-1

(7-fluoro-2-oxo-1(2H)-quinolinyl)acetaldehyde

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

1,1-dimethylethyl {1-[2-(7-fluoro-2-oxo-1(2H)-quinolinyl)ethyl]-4-piperidinyl}carbamate
917341-51-6

1,1-dimethylethyl {1-[2-(7-fluoro-2-oxo-1(2H)-quinolinyl)ethyl]-4-piperidinyl}carbamate

Conditions
ConditionsYield
Stage #1: (7-fluoro-2-oxo-1(2H)-quinolinyl)acetaldehyde; (piperidin-4-yl)carbamic acid tert-butyl ester In methanol; chloroform at 20℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In methanol; chloroform at 20℃; for 2.83333h;
100%
dimethylaminoacetic acid
1118-68-9

dimethylaminoacetic acid

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl [1-(2-dimethylaminoacetyl)piperidin-4-yl]carbamate
864246-28-6

tert-butyl [1-(2-dimethylaminoacetyl)piperidin-4-yl]carbamate

Conditions
ConditionsYield
Stage #1: dimethylaminoacetic acid; (piperidin-4-yl)carbamic acid tert-butyl ester With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 46h;
Stage #2: With sodium hydroxide In water; ethyl acetate; N,N-dimethyl-formamide; sodium chloride at 20℃; for 0.5h;
100%
With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 46h;100%
(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

2-bromoethanol
540-51-2

2-bromoethanol

[1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester
558443-53-1

[1-(2-hydroxyethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 5h; Inert atmosphere; Reflux;100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h; Inert atmosphere;97%
With potassium carbonate In acetonitrile for 5h; Heating;94%
(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

4-chloro-5-phenyl-thieno[2,3-d]pyrimidine
182198-35-2

4-chloro-5-phenyl-thieno[2,3-d]pyrimidine

[1-(5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester

[1-(5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In ethylene glycol at 110℃; for 3h;100%
With triethylamine In isopropyl alcohol for 2h; Heating / reflux;75%
In ethylene glycol at 110℃; for 4h;
3-(Trifluoromethyl)benzoyl chloride
2251-65-2

3-(Trifluoromethyl)benzoyl chloride

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

C18H23F3N2O3
672324-63-9

C18H23F3N2O3

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 25℃; for 3.25h;100%
1,4-difluoro-2-nitrobenzene
364-74-9

1,4-difluoro-2-nitrobenzene

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl 1-(4-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate
885115-60-6

tert-butyl 1-(4-fluoro-2-nitrophenyl)piperidin-4-ylcarbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 70℃; for 3.5h;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

1-(pyridin-2-ylmethyl)piperidin-4-amine tris(hydrochloride)

1-(pyridin-2-ylmethyl)piperidin-4-amine tris(hydrochloride)

Conditions
ConditionsYield
Stage #1: pyridine-2-carbaldehyde; (piperidin-4-yl)carbamic acid tert-butyl ester With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane at 20℃;
Stage #2: With hydrogenchloride In methanol; diethyl ether at 20℃;
100%
(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

4-chloro-2-(2'-hydroxyphenyl)quinazoline
25171-36-2

4-chloro-2-(2'-hydroxyphenyl)quinazoline

tert-butyl 1-(2-(2-hydroxyphenyl)quinazolin-4-yl)piperidin-4-ylcarbamate

tert-butyl 1-(2-(2-hydroxyphenyl)quinazolin-4-yl)piperidin-4-ylcarbamate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;100%
(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

6-{4-[2-(4-Amino-piperidin-1-yl)-ethyl]-phenyl}-pyridin-2-ylamine

6-{4-[2-(4-Amino-piperidin-1-yl)-ethyl]-phenyl}-pyridin-2-ylamine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane100%
methyl 5-[6-(chloromethyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate
929095-40-9

methyl 5-[6-(chloromethyl)-1H-benzimidazol-1-yl]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

methyl 5-(6-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

methyl 5-(6-{[4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-1-piperidinyl]methyl}-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)-2-thiophenecarboxylate

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane at 20℃; for 18h;100%
9-fluoro-1-(hydroxymethyl)-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl 4-methylbenzenesulfonate
944407-62-9

9-fluoro-1-(hydroxymethyl)-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl 4-methylbenzenesulfonate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

1,1-dimethylethyl {1-[(9-fluoro-1-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)methyl]-4-piperidinyl}carbamate
944407-63-0

1,1-dimethylethyl {1-[(9-fluoro-1-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)methyl]-4-piperidinyl}carbamate

Conditions
ConditionsYield
With sodium carbonate In ethanol; water100%
With sodium carbonate In ethanol at 20℃; for 16h;100%
With sodium carbonate In ethanol at 20℃; for 16h;100%
4-Chloro-5-(thien-2-yl)thieno[2,3-d]pyrimidine

4-Chloro-5-(thien-2-yl)thieno[2,3-d]pyrimidine

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

C20H24N4O2S2

C20H24N4O2S2

Conditions
ConditionsYield
In ethylene glycol at 110℃; for 6h;100%
In ethylene glycol at 110℃; for 4h;
(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

(4-aminopiperidin-1-yl)acetonitrile dihydrochloride

(4-aminopiperidin-1-yl)acetonitrile dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol at 40℃;100%
4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid
863250-63-9

4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

4-{[4-(benzofuran-3-ylmethoxy)-1H-indole-2-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester
863252-14-6

4-{[4-(benzofuran-3-ylmethoxy)-1H-indole-2-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: 4-(benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) at 0℃; for 0.166667h;
Stage #2: (piperidin-4-yl)carbamic acid tert-butyl ester With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In DMF (N,N-dimethyl-formamide) at 20℃;
100%
styrene oxide
96-09-3

styrene oxide

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

[1-(2-Hydroxy-2-phenyl-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester
1269606-74-7

[1-(2-Hydroxy-2-phenyl-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
100%
3,5-dichloro-2-hydroxybenzenesulfonyl chloride
23378-88-3

3,5-dichloro-2-hydroxybenzenesulfonyl chloride

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

C16H22Cl2N2O5S
1417652-18-6

C16H22Cl2N2O5S

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane100%
(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

acrylonitrile
107-13-1

acrylonitrile

[1-(2-cyano-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester
898271-16-4

[1-(2-cyano-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
In ethanol at 80℃; for 2h;100%
(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide
1401066-79-2

(2R,3S)-N-((3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3- trifluoropropyl)succinamide

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl 1-(((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl 2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)methyl)piperidin-4-yl carbamate
1581704-69-9

tert-butyl 1-(((2S,3R)-6,6,6-trifluoro-3-((S,Z)-1-methyl-2-oxo-5-phenyl 2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylcarbamoyl)-2-(3,3,3-trifluoropropyl)hexanamido)methyl)piperidin-4-yl carbamate

Conditions
ConditionsYield
With formaldehyd In ethanol at 75℃; for 18h;100%
4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzaldehyde

4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzaldehyde

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl 1-(4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzyl)piperidin-4-ylcarbamate

tert-butyl 1-(4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzyl)piperidin-4-ylcarbamate

Conditions
ConditionsYield
Stage #1: 4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)benzaldehyde; (piperidin-4-yl)carbamic acid tert-butyl ester With acetic acid In dichloromethane at 50℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 2h; Cooling with ice;
100%
o-bromobenzenesulfonyl chloride
2905-25-1

o-bromobenzenesulfonyl chloride

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

tert-butyl (1-((2-bromophenyl)sulfonyl)piperidin-4-yl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1.5h; Inert atmosphere;100%
2-(4-cyano-3-fluorophenyl)-5-methyl-1-(2-methylindazol-5-yl)imidazole-4-carboxylic acid

2-(4-cyano-3-fluorophenyl)-5-methyl-1-(2-methylindazol-5-yl)imidazole-4-carboxylic acid

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

C30H32FN7O3

C30H32FN7O3

Conditions
ConditionsYield
With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 1h;100%
6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate
163083-48-5

6-methyl-2-nitropyridin-3-yl trifluoromethanesulfonate

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl (1-(6-methyl-2-nitropyridin-3-yl)piperidin-4-yl)carbamate

tert-butyl (1-(6-methyl-2-nitropyridin-3-yl)piperidin-4-yl)carbamate

Conditions
ConditionsYield
With triethylamine In acetonitrile for 8h; Reflux;100%
6-chloropyridazine-3-carbonitrile
35857-89-7

6-chloropyridazine-3-carbonitrile

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

(1-(6-cyano-pyridazin-3-yl)piperidin-4-yl)-carbamic acid tert-butylester

(1-(6-cyano-pyridazin-3-yl)piperidin-4-yl)-carbamic acid tert-butylester

Conditions
ConditionsYield
With triethylamine In ethanol at 20℃;100%
With triethylamine In ethanol at 20℃;100%
With triethylamine In ethanol at 20℃;100%
3-bromo-4-chloro-5-nitropyridine
31872-63-6

3-bromo-4-chloro-5-nitropyridine

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl N-(1-(3-bromo-5-nitro-4-pyridinyl)-4-piperidinyl)carbamate

tert-butyl N-(1-(3-bromo-5-nitro-4-pyridinyl)-4-piperidinyl)carbamate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;100%
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;59.7 g
With triethylamine In tetrahydrofuran for 1h; Cooling with ice;59.78 g
p-Methoxybenzyl bromide
2746-25-0

p-Methoxybenzyl bromide

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl (1-(4-methoxybenzyl)piperidin-4-yl)carbamate

tert-butyl (1-(4-methoxybenzyl)piperidin-4-yl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;100%
With potassium carbonate In N,N-dimethyl-formamide at 40℃; for 1h;81%
With triethylamine In ethanol
4-chloro-2-methoxynicotinic aldehyde
1008451-58-8

4-chloro-2-methoxynicotinic aldehyde

(piperidin-4-yl)carbamic acid tert-butyl ester
73874-95-0

(piperidin-4-yl)carbamic acid tert-butyl ester

tert-butyl N-[1-(3-formyl-2-methoxypyridin-4-yl)piperidin-4-yl]carbamate

tert-butyl N-[1-(3-formyl-2-methoxypyridin-4-yl)piperidin-4-yl]carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 100℃; for 0.666667h;100%

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