5-Pyrimidinecarboxylic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxypropyl]-1,2,3, 4-tetrahydro-6-methyl-2-oxo-1,3-bis(phenylmethyl)-, ethyl ester

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxypropyl]-1,2,3, 4-tetrahydro-6-methyl-2-oxo-1,3-bis(phenylmethyl)-, ethyl ester
CAS No.:596828-06-7
Molecular Formula:C30H39N3O6
Molecular Weight:537.656
Hs Code.:

5-Pyrimidinecarboxylic acid,
4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxypropyl]-1,2,3,
4-tetrahydro-6-methyl-2-oxo-1,3-bis(phenylmethyl)-, ethyl ester

Synonyms:

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Chemical Property of 5-Pyrimidinecarboxylic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxypropyl]-1,2,3, 4-tetrahydro-6-methyl-2-oxo-1,3-bis(phenylmethyl)-, ethyl ester

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Technology Process of 5-Pyrimidinecarboxylic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxypropyl]-1,2,3, 4-tetrahydro-6-methyl-2-oxo-1,3-bis(phenylmethyl)-, ethyl ester

There total 3 articles about 5-Pyrimidinecarboxylic acid, 4-[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-hydroxypropyl]-1,2,3, 4-tetrahydro-6-methyl-2-oxo-1,3-bis(phenylmethyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 596828-30-7
(4''S)-1,3-di-N-benzyl-4-(3''-tert-butoxycarbonyl-2'',2''-dimethyloxazolidin-4''-ylmethyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

: 596828-06-7
(2'S)-1,3-di-N-benzyl-4-(2'-tert-butoxycarbonylamino-3'-hydroxypropyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With water; acetic acid; at 20 ℃;
DOI:10.1021/jo0342830

Reference yield:

: 100-39-0
benzyl bromide

: 596828-06-7
(2'S)-1,3-di-N-benzyl-4-(2'-tert-butoxycarbonylamino-3'-hydroxypropyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaH / dimethylformamide; various solvent(s) / 2 h / 20 °C

2: AcOH; H₂O / 20 °C

With water; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo0342830

Reference yield:

: (4''S)-4-(3''-tert-butoxycarbonyl-2'',2''-dimethyloxazolidin-4''-ylmethyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

: 596828-06-7
(2'S)-1,3-di-N-benzyl-4-(2'-tert-butoxycarbonylamino-3'-hydroxypropyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaH / dimethylformamide; various solvent(s) / 2 h / 20 °C

2: AcOH; H₂O / 20 °C

With water; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jo0342830